Myofibroblast phenotypes expression in experimental renal scarring

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
E C Muchaneta-Kubara, A M El Nahas

Abstract

Myofibroblasts have been implicated in the pathogenesis of wound healing and tissue fibrosis. A role has also been put forward for these cells in the development of experimental and clinical renal scarring. We examined the expression of myofibroblast phenotypes by immunohistochemistry, relying on an avidin-biotin-peroxidase method, during the course of renal scarring in rats submitted to subtotal (5/6) nephrectomy (SNx). We also attempted to identify changes in immunoreactive transforming growth factor-beta (TGF-beta) and collagen (III and IV) within remnant kidneys in order to determine their association with the expression of the myofibroblasts. In normal sham-operated rats, alpha-smooth muscle actin (alpha-SMA) was confined to the media of renal arteries and arterioles. In contrast, in rats with renal ablation we observed the early (day 7) appearance of myofibroblasts expressing alpha-SMA (A) in the interstitium of remnant kidneys particularly around vessels. Interstitial cells expressing alpha-SMA increased with time as tubulointerstitial fibrosis progressed. By day 30 some interstitial cells also expressed vimentin (V). Various interstitial myofibroblast phenotypes (A, V, VA) were expressed during the course of experimenta...Continue Reading

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