Myogenic and proteolytic mRNA expression following blood flow restricted exercise.

Acta Physiologica
Todd M ManiniBrian C Clark

Abstract

Resistance exercise performed at low loads (20-30% of maximal strength) with blood flow restriction (BFR) acutely increases protein synthesis and induces hypertrophy when performed chronically. We investigated myogenic and proteolytic mRNA expression 8 h following an acute bout of knee extension exercise. Fifteen subjects (22.8 ± 3.7 years, eight men and seven women) were randomized to two exercise conditions: BFR or control exercise. All participants performed four sets of exercise (30, 15, 15 and 15 repetitions) at 20% of maximal strength. Persons in the BFR group had a cuff placed on the upper thigh inflated to 1.5 times brachial systolic blood pressure (cuff pressure range: 135-186 mmHg). Muscle biopsies from the vastus lateralis were excised 24 h before and 8 h following the exercise.   RT-PCR analysis demonstrated no change in myogenic gene expression (insulin-like growth factor-1, MyoD, myogenin, myostatin - a negative regulator) with either exercise condition (P > 0.123). However, BFR exercise downregulated mRNA expression in transcripts associated with proteolytic pathways (FOXO3A, Atrogin-1 and MuRF-1) with no change in the control exercise condition. Specifically, median mRNA expression of FOXO3A decreased by 1.92-fo...Continue Reading

References

Dec 1, 1995·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·J D MacDougallK E Yarasheski
Mar 1, 1996·Journal of Applied Physiology·T HortobágyiR G Israel
Mar 20, 2001·International Journal of Sport Nutrition and Exercise Metabolism·K D Tipton, R R Wolfe
Dec 1, 2001·Journal of Strength and Conditioning Research·L L Ploutz-Snyder, E L Giamis
Feb 6, 2002·Medicine and Science in Sports and Exercise·William J KraemerUNKNOWN American College of Sports Medicine
Sep 18, 2004·Archives of Physical Medicine and Rehabilitation·Brian C ClarkLori L Ploutz-Snyder
Nov 2, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristian VissingPeter Schjerling
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeong-su KimMarcas M Bamman
Apr 15, 2005·Journal of Applied Physiology·James G Tidball
Mar 31, 2007·Journal of Applied Physiology·Marcas M BammanJames M Cross
Nov 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Henrik MascherEva Blomstrand
Mar 5, 2008·Medicine and Science in Sports and Exercise·Micah J DrummondBlake B Rasmussen
Jul 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·David S WaddellSue C Bodine
Mar 24, 2009·Exercise and Sport Sciences Reviews·Todd M Manini, Brian C Clark
Sep 4, 2009·European Journal of Applied Physiology·Jonathan D UmbelBrian C Clark
Nov 21, 2009·Medicine and Science in Sports and Exercise·Bruno GualanoCarlos Ugrinowitsch
Feb 13, 2010·Journal of Applied Physiology·Christopher S FryBlake B Rasmussen

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Citations

Dec 7, 2011·European Journal of Applied Physiology·Jeremy P LoennekeMichael G Bemben
May 8, 2013·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jeremy P LoennekeTakashi Abe
Feb 22, 2012·Acta Physiologica·B ElliottR Mackenzie
Jan 1, 2012·Extreme Physiology & Medicine·Kyle J HackneyLori Ploutz-Snyder
May 25, 2011·Medicine and Science in Sports and Exercise·Dillon K WalkerBlake B Rasmussen
Jun 9, 2012·Medicine and Science in Sports and Exercise·Kelly A LarkinThomas W Buford
Dec 24, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Thomas W BufordMatthew B Cooke
Apr 10, 2014·Sports Medicine·Brendan R ScottBen J Dascombe
Dec 15, 2015·Experimental Physiology·David AguayoMarco Toigo
Nov 3, 2012·The Journal of Physiology·Jeremy P LoennekeLindy M Rossow
Jun 16, 2011·Biochemical and Biophysical Research Communications·Akiko OndaToru Fukubayashi
Jun 12, 2012·Clinical Physiology and Functional Imaging·Takashi AbeMichael G Bemben
Jan 3, 2013·Scandinavian Journal of Medicine & Science in Sports·J Martín-HernándezA J Herrero
Mar 22, 2014·Scandinavian Journal of Medicine & Science in Sports·J P LoennekeT Abe
Dec 15, 2012·Acta Physiologica Hungarica·Jeremy Paul LoennekeM G Bemben
Sep 10, 2013·Acta Physiologica Hungarica·Juan Martín-HernándezA J Herrero
Sep 18, 2012·Acta Physiologica Hungarica·J P LoennekeM G Bemben
Mar 19, 2014·Medical Hypotheses·J P LoennekeM G Bemben
Oct 13, 2016·Clinical Physiology and Functional Imaging·Brittany R CountsJeremy P Loenneke
Dec 22, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Andrew S LayneThomas W Buford
Sep 14, 2018·The Journal of Orthopaedic and Sports Physical Therapy·Colin W BondBenjamin C Noonan
Jul 17, 2018·Journal of Strength and Conditioning Research·Paul S Hwang, Darryn S Willoughby
Apr 3, 2014·American Journal of Physiology. Endocrinology and Metabolism·David M GundermannBlake B Rasmussen
Sep 7, 2018·Medicine and Science in Sports and Exercise·Thomas BjørnsenTruls Raastad
Dec 12, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher PignanelliJamie F Burr
Jun 26, 2015·Medicine and Science in Sports and Exercise·Toshiharu NatsumeHisashi Naito
Feb 1, 2013·Journal of Strength and Conditioning Research·Zachary K PopeBrad J Schoenfeld
Jul 24, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stian EllefsenBent R Rønnestad

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