Myogenic basic helix-loop-helix proteins regulate the expression of peroxisomal proliferator activated receptor-gamma coactivator-1alpha

Endocrinology
Ju Hui ChangShen Liang Chen

Abstract

Peroxisomal proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), a transcriptional coactivator, is selectively expressed in slow-twitch fibers in skeletal muscle. Ectopic expression of the PGC-1alpha gene in either a cell or an animal has been shown to promote fast to slow fiber-type switch. The expression of PGC-1alpha in muscle is regulated by myocyte enhancer factor 2 and Forkhead in rhabdomyosarcoma, two transcription factors implicated in terminal muscle differentiation. In this study we found that PGC-1alpha expression was activated during terminal muscle differentiation in both C2C12 and Sol8 myoblasts. Using retrovirus-mediated MyoD overexpression in C3H10T1/2 cells, we also demonstrated that MyoD, the master regulator of terminal differentiation, could activate PGC-1alpha expression in vivo. Our transient transfection results also show that myogenic basic helix-loop-helix (bHLH) proteins, especially MyoD, can activate PGC-1alpha expression by targeting its promoter. Myogenic bHLH protein target sites on PGC-1alpha promoter were localized to a short region (-49 to approximately +2) adjacent to the transcription start site, which contains two putative E boxes. Mutation of either site significantly reduc...Continue Reading

References

Nov 15, 1985·Science·H M BlauC Webster
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D Molkentin, E N Olson
Jun 1, 1996·Trends in Genetics : TIG·G CossuM Buckingham
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Apr 5, 2000·The Journal of Biological Chemistry·I TcherepanovaD P McDonnell
Nov 21, 2001·The Journal of Biological Chemistry·Philippe DeleriveChen S Suen
Mar 5, 2002·The Journal of Biological Chemistry·Hannes OberkoflerWolfgang Patsch
Sep 21, 2002·Molecular and Cellular Biology·Michael P SpillerMridula Sharma
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Michael P CzubrytEric N Olson
Feb 18, 2003·Journal of Anatomy·Margaret BuckinghamFrédéric Relaix
May 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christoph HandschinBruce M Spiegelman
Mar 27, 2004·American Journal of Physiology. Cell Physiology·Eva ZebedinKarlheinz Hilber

❮ Previous
Next ❯

Citations

Feb 3, 2007·Pflügers Archiv : European journal of physiology·Ibtissem GuerfaliDamien Freyssenet
Oct 24, 2007·QJM : Monthly Journal of the Association of Physicians·A A SayerUNKNOWN Hertfordshire Cohort
Nov 3, 2010·Biological Reviews of the Cambridge Philosophical Society·Kristian Gundersen
Nov 22, 2013·Seminars in Immunopathology·Petra S Eisele, Christoph Handschin
Dec 3, 2013·General and Comparative Endocrinology·Chi-Wei LiuYung-Hsi Kao
Feb 22, 2012·The Journal of Cell Biology·Nadine BakkarDenis C Guttridge
Jul 17, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Bradley S GordonMatthew C Kostek
Dec 1, 2006·FEBS Letters·Tamás Arányi, András Páldi
Mar 11, 2009·Differentiation; Research in Biological Diversity·Joanne P KarunaratneNeil C Stickland
Jun 16, 2009·The Biochemical Journal·Sheng P HsiaoShen L Chen
Mar 26, 2010·The Biochemical Journal·Sheng Pin Hsiao, Shen Liang Chen
May 4, 2013·Bioscience Reports·Shih Ying ChungShen Liang Chen
Dec 24, 2013·Molecular and Cellular Endocrinology·Han Fang TengShen Liang Chen
May 13, 2015·Molecular and Cellular Biology·Shih Ying ChungShen Liang Chen
Mar 13, 2009·Organogenesis·Charlotte A Maltin
Oct 1, 2019·Journal of Cachexia, Sarcopenia and Muscle·Nima GharahdaghiPhilip J Atherton
Feb 3, 2021·The Biochemical Journal·Yung-Jui LinShen-Liang Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.