Myogenic tone in coronary arteries from spontaneously hypertensive rats

Journal of Vascular Research
S R GarciaS J Bund

Abstract

The aims of this study were to investigate myogenic tone in cannulated coronary arteries from SHR (spontaneously hypertensive rats) and WKY (Wistar-Kyoto rats) at 5 and 20 weeks of age under pressurised no-flow conditions. Pressure-diameter relationships (20-200 mm Hg) were determined in the presence (active) and absence (passive) of calcium and myogenic tone at each pressure was calculated. Active, but not passive diameter-pressure relationships were significantly different between strains at both ages. Active diameters were similar between strains at pressures up to 140 mm Hg at 5 and 20 weeks. At higher pressures SHR arteries generated more tone. Maximum myogenic tone was similar between strains in spite of increased wall thickness in the SHR at both ages. Endothelium denudation increased myogenic tone to a greater extent in the SHR at both ages. Active diameters of endothelium-denuded SHR arteries were smaller than those of WKY in the range 20-120 mm Hg at 5 week and 20-80 and 160-180 mm Hg at 20 weeks. These results demonstrate that during both the developmental and established phases of hypertension, myogenic tone is not enhanced in intact SHR coronary arteries, except at the highest pressures. Following endothelium remov...Continue Reading

Citations

Aug 26, 2003·Microvascular Research·Samir S UndaviaEdward J Messina
Jul 16, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eun Bok Baek, Sung Joon Kim
Jan 9, 2010·Vascular Health and Risk Management·Andrew S LevyJames W E Rush
Sep 12, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Filiz GündüzHerbert J Meiselman
Feb 13, 2016·Genetic Testing and Molecular Biomarkers·Cigdem Yuce KahramanAbdulgani Tatar
Mar 10, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ashley S IzzardAnthony M Heagerty
Jan 13, 2004·Journal of Cardiovascular Pharmacology·Maria SzekeresAkos Koller
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·P VéquaudJ L Freslon
Mar 19, 2003·Hypertension·Simone GschwendHendrik Buikema
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Nov 24, 1999·The American Journal of Physiology·T R Nurkiewicz, M A Boegehold
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Robert GrosMansoor Husain
Apr 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·D G HemmingsS T Davidge
Feb 26, 2020·Journal of Vascular Research·Peter D YimCharles W Emala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.