Myogenin regulates a distinct genetic program in adult muscle stem cells

Developmental Biology
Eric MeadowsW H Klein

Abstract

In contrast to the detailed understanding we have for the regulation of skeletal muscle gene expression in embryos, similar insights into postnatal muscle growth and regeneration are largely inferential or do not directly address gene regulatory mechanisms. Muscle stem cells (satellite cells) are chiefly responsible for providing new muscle during postnatal and adult life. The purpose of this study was to determine the role that the myogenic basic helix-loop-helix regulatory factor myogenin has in postnatal muscle growth and adult muscle stem cell gene expression. We found that myogenin is absolutely required for skeletal muscle development and survival until birth, but it is dispensable for postnatal life. However, Myog deletion after birth led to reduced body size implying a role for myogenin in regulating body homeostasis. Despite a lack of skeletal muscle defects in Myog-deleted mice during postnatal life and the efficient differentiation of cultured Myog-deleted adult muscle stem cells, the loss of myogenin profoundly altered the pattern of gene expression in cultured muscle stem cells and adult skeletal muscle. Remarkably, these changes in gene expression were distinct from those found in Myog-null embryonic skeletal musc...Continue Reading

References

Jan 1, 1987·Current Topics in Developmental Biology·G Cossu, M Molinaro
Mar 1, 1985·Muscle & Nerve·E SchultzC R Valliere
Feb 1, 1995·The Journal of Cell Biology·J M VenutiW H Klein
Dec 31, 1993·Cell·M A RudnickiR Jaenisch
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J F MartinE N Olson
May 1, 1996·The International Journal of Biochemistry & Cell Biology·M BenitoM Lorenzo
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Mar 25, 2000·Clinical Genetics·L A Sabourin, M A Rudnicki
Apr 15, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J K LeeH Suh-Kim
Apr 18, 2001·The Journal of Biological Chemistry·L C van KempenG W Swart
Jul 19, 2001·Physiological Genomics·F KernecA P Koretsky
Apr 30, 2003·Arthritis Research & Therapy·Hideaki Nagase, Masahide Kashiwagi
Jul 31, 2003·Trends in Cell Biology·Marianna B Ruzinova, Robert Benezra
Sep 10, 2003·Cell Cycle·Grace K Pavlath, Valerie Horsley
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Mar 23, 2004·Annual Review of Immunology·Warren S Alexander, Douglas J Hilton
Apr 16, 2004·American Journal of Physiology. Cell Physiology·Brenda A BondesenGrace K Pavlath
Sep 24, 2004·Nature·Lina Kassar-DuchossoyShahragim Tajbakhsh
Jan 18, 2005·The Journal of Biological Chemistry·Espen E Spangenburg
Apr 1, 2005·Nature·Heather StantonAmanda J Fosang
Aug 16, 2005·Seminars in Cell & Developmental Biology·Charlotte A Berkes, Stephen J Tapscott
Oct 21, 2005·Biochimica Et Biophysica Acta·Uwe SchlattnerTheo Wallimann
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Robert P KrugerKun-Liang Guan
Feb 18, 2006·The Journal of Physiology·Espen E SpangenburgRussell L Moore
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marko JevsekSteven J Burden
May 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Brenda A BondesenGrace K Pavlath
Jan 26, 2008·Trends in Molecular Medicine·Shihuan Kuang, Michael A Rudnicki

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Citations

May 3, 2014·PloS One·Xiaomei GeHonglin Jiang
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ning LiuEric N Olson
Mar 26, 2014·Cellular and Molecular Life Sciences : CMLS·Giuliana Rossi, Graziella Messina
Jan 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Jong-Sun Kang, Robert S Krauss
Feb 10, 2011·Molecular Genetics and Genomics : MGG·Shuang ZhangJudith K Davie
Nov 8, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kristen M GaworeckiLisa J Bain
Apr 22, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Minghui WangYuchun Pan
Dec 23, 2009·The Journal of Cell Biology·Mark A GillespieMichael A Rudnicki
Sep 11, 2010·Experimental Cell Research·Keren Bismuth, Frédéric Relaix
Sep 22, 2009·Journal of Internal Medicine·S Tajbakhsh
Jun 28, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Chen-Ming FanChristoph Lepper
Oct 9, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dana M CairnsLi Zeng
Oct 23, 2012·The International Journal of Biochemistry & Cell Biology·Takahiro SuzukiRyuichi Tatsumi
Jul 7, 2015·Skeletal Muscle·Luciana De AngelisLibera Berghella
Jun 15, 2016·Biological Reviews of the Cambridge Philosophical Society·Judy E AndersonRyuichi Tatsumi
Aug 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Soundharrajan IlavenilKi Choon Choi
May 10, 2017·Stem Cells·Ryuichi TatsumiRonald E Allen
Dec 8, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Zipora Yablonka-Reuveni
Oct 27, 2017·Journal of Lipid Research·Boubacar BenzianeJuleen R Zierath
Nov 30, 2011·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Alexander SpassovChristiane Kunert-Keil
Jan 10, 2019·EMBO Reports·Keisuke HitachiKunihiro Tsuchida
Apr 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiwei LiShufeng Li
Jul 1, 2020·The FEBS Journal·Yaiza Núñez-ÁlvarezMònica Suelves
May 1, 2018·PloS One·Jordana Miranda de Souza SilvaRicardo Machado Xavier
Oct 14, 2018·Nature Communications·Massimo GanassiSimon M Hughes
May 28, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Tomasz PodgorniakJorge M O Fernandes
Jul 23, 2020·Cell and Tissue Research·Can CuiHuadong Yin

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