Myoinformatics report: myosin regulatory light chain paralogs in the human genome

Journal of Muscle Research and Cell Motility
John H Collins

Abstract

On-line bioinformatics tools were used to identify and characterize all paralogs (intragenomic homologs) of muscle myosin regulatory light chains in the human genome. The initial search yielded 22 possible paralogs, but careful examination of supporting data eliminated most of these. Five paralogs were clearly identified with the tissue types (skeletal and cardiac muscles, smooth muscle, non-muscle cytoplasm) in which they are expressed. Sequence comparisons and phylogenetic analysis showed early divergence of a common ancestor of smooth muscle and non-muscle paralogs from a common ancestor of skeletal and cardiac muscle paralogs. An unusual sixth human paralog was very similar to the regulatory light chain of "superfast" myosin, which to date has been found only in cat. Finally, a unique and questionable "precursor lymphocyte" paralog was tentatively identified. Three-dimensional structural models of all seven human paralogs were constructed using the known structure of chicken fast skeletal muscle regulatory light chain as a template.

References

Oct 11, 1990·Nucleic Acids Research·J W GrantS L Church
Mar 21, 2000·Biochimica Et Biophysica Acta·J R Sellers
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A HoudusseC Cohen
Jul 27, 2001·Journal of Structural Biology·L F ChenK A Taylor
Oct 9, 2002·Current Protein & Peptide Science·D XuE C Uberbacher
Dec 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert L StrausbergUNKNOWN Mammalian Gene Collection Program Team
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dipesh RisalCarolyn Cohen

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Citations

Sep 22, 2007·The Journal of Clinical Investigation·Osamu SeguchiMasafumi Kitakaze
Dec 4, 2020·Nature·Charlotte A ScarffMichelle Peckham
Oct 22, 2008·Journal of Molecular and Cellular Cardiology·Michael J GreenbergJeffrey R Moore
Feb 3, 2011·Archives of Biochemistry and Biophysics·James T StullRene Vandenboom

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