Myokine interleukin-15 expression profile is different in suckling and weaning piglets

Animal Nutrition
Yehui DuanYulong Yin

Abstract

Interleukin-15 (IL-15) is a cytokine highly expressed in skeletal muscle. The objective of the present study was to investigate the development of muscle IL-15 expression in suckling piglets and in early weaning piglets (day 14) at each level, that is, mRNA, protein, and secretion. Eight litters (eight piglets per litter) of newborn healthy piglets (Large × White × Landrace) with a similar initial weight (1618.0 ± 140.1 g) were chosen and divided into two groups. Group one used suckling piglets that were killed, respectively, at days 1, 7, 14, 21, and group two used early (day 14) weaning piglets that were killed respectively, at days 15, 17, 19, 21. In group one, IL-15 gene expression levels increased significantly (P < 0.05) along with increased body weight over time. IL-15 protein expression levels in piglets at day 21 of age were higher (P < 0.05) than those in piglets at other ages, and there was no difference (P > 0.05) among piglets at other ages. These findings indicated that increased IL-15 mRNA expression did not result in a corresponding increase of its protein expression. In group two, which used early weaning piglets from days 15-19, IL-15 mRNA and protein expression levels increased constantly (P < 0.05) and were ...Continue Reading

Citations

Jul 17, 2018·Journal of Animal Physiology and Animal Nutrition·Yehui H DuanLingyu Y Zhang
Oct 10, 2018·Journal of the Science of Food and Agriculture·Yehui DuanXiangfeng Kong
Jun 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yehui DuanXiangfeng Kong
Feb 2, 2021·Frontiers in Veterinary Science·Zhilong TianXiangfeng Kong

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