Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise.

Current Opinion in Pharmacology
Michael T ParisMarina Mourtzakis

Abstract

Detrimental age-associated changes in skeletal muscle and adipose tissue increase the risk of sarcopenia. Age-related changes in myokines, such as myostatin and irisin, as well as adipokines, such as leptin and adiponectin, contribute to cross-talk between muscle and adipose tissue. These age-related changes in myokines and adipokines have important implications for sarcopenia, however, recent literature highlights discrepancies in these relationships. Exercise may alter serum profiles and muscle receptor expression of these factors, but future work is needed to determine whether these changes in myokines and adipokines relate to improvements in muscle mass and function. Here, we describe myokine-mediated and adipokine-mediated interactions between muscle and adipose tissue, and discuss the fundamental importance of these cytokines to understanding the development of sarcopenia.

References

Aug 25, 2009·Molecular and Cellular Endocrinology·Erika A F R RomanMarcio A Torsoni
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Mar 9, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A RatkeviciusH Wackerhage
Sep 5, 2013·Molecular Endocrinology·Craig A GoodmanTroy A Hornberger
Feb 20, 2015·Diabetes·Vanessa PellegrinelliDanièle Lacasa
May 31, 2016·Journal of Cachexia, Sarcopenia and Muscle·Tahnee SenteChristiaan J Vrints
Aug 31, 2016·Aging Clinical and Experimental Research·Busra CanZekeriya Ulger
Apr 13, 2017·Aging and Disease·Alberto LanaEsther Lopez-Garcia
Jul 22, 2017·Journal of Applied Physiology·Ismael Perez-SuarezJose A L Calbet
Dec 22, 2017·Diabetes·Claudia Menzaghi, Vincenzo Trischitta
Feb 14, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joshua F BakerTamara B Harris
Apr 15, 2018·Journal of Cachexia, Sarcopenia and Muscle·Li-Ning PengLiang-Kung Chen
Jun 21, 2018·PloS One·James ReneauSrividya Kidambi
Aug 4, 2018·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Melina AmorThomas M Stulnig
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Apr 3, 2019·International Journal of Molecular Sciences·Matthew P KrauseThomas J Hawke
May 12, 2019·BMC Musculoskeletal Disorders·Ryo TazawaMasashi Takaso
Jun 5, 2019·BMC Endocrine Disorders·Salah GariballaAwad Al Essa
Jul 30, 2019·Frontiers in Physiology·Cristina Planella-FarrugiaJosé Manuel Fernández-Real
Sep 3, 2019·Frontiers in Cardiovascular Medicine·Masato IwabuTakashi Kadowaki
Apr 3, 2020·Redox Biology·Javier AnguloLeocadio Rodríguez-Mañas

❮ Previous
Next ❯

Citations

Aug 28, 2021·The FEBS Journal·Song Ah ChaeMin Du

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.