Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases.

Current Osteoporosis Reports
G ColaianniMaria Grano

Abstract

In this review we aim to summarize the latest findings on the network of molecules produced by muscle and bone under physiological and pathological conditions. The concomitant onset of osteoporosis and sarcopenia is currently one of the main threats that can increase the risk of falling fractures during aging, generating high health care costs due to hospitalization for bone fracture surgery. With the growing emergence of developing innovative therapies to treat these two age-related conditions that often have common onset, a broader understanding of molecular messengers regulating the communication between muscle and bone tissue became imperative. Recently it has been highlighted that two muscle-derived signals, such as the myokines Irisin and L-BAIBA, positively affect bone tissue. In parallel, there are signals derived from bone that affect either positively the skeletal muscle, such as osteocalcin, or negatively, such as RANKL.

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Citations

Jan 9, 2021·Seminars in Reproductive Medicine·Navira SamadFrances Milat
Nov 29, 2020·Experimental Gerontology·Fabiana TanganelliMichael Drey
Feb 11, 2021·International Journal of Molecular Sciences·Patrizia PignataroMaria Grano
Mar 19, 2021·Frontiers in Endocrinology·Sonja BuvinicViviana Toro-Ibacache
Apr 27, 2021·Experimental Biology and Medicine·Fabrizio PinAndrea Bonetto
May 1, 2021·Metabolites·Kana MiyamotoTakeshi Miyamoto

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