PMID: 8594024Nov 1, 1995Paper

Myoneural interactions affect diaphragm muscle adaptations to inactivity

Journal of Applied Physiology
H MiyataGary C Sieck

Abstract

We hypothesized that inactivity effects on diaphragm muscle contractile and morphometric properties are attenuated if phrenic motoneurons are also inactive. Three models of rat diaphragm inactivity were compared: 1) spinal isolation; 2) tetrodotoxin (TTX) nerve blockade; and 3) denervation (Dnv). Motoneuron and muscle fiber inactivities were matched only in spinal isolated animals. After 2 wk, maximum tetanic force decreased in all three groups compared with control group but to a greater extent in TTX and Dnv animals. Fatigue resistance improved, and maximum unloaded shortening velocity slowed only in TTX and Dnv groups. Type IIa fiber proportions decreased in all three groups, and type IIx fiber proportions increased in TTX and Dnv animals. Type I fiber cross-sectional area increased in all three groups but to a greater extent in TTX and Dnv animals. Type IIa fibers hypertrophied, whereas type IIx and IIb fibers atrophied only in TTX and Dnv groups. These results support the hypothesis that muscle adaptations to prolonged inactivity are attenuated when muscle fiber and motoneuron inactivities are matched.

Citations

Nov 1, 1996·Journal of Applied Physiology·M I LewisG C Sieck
Feb 7, 2003·Journal of Applied Physiology·Carlos B Mantilla, Gary C Sieck
Apr 22, 2003·Journal of Applied Physiology·Paige C GeigerGary C Sieck
Jan 18, 2006·Journal of Applied Physiology·Bharathi AravamudanGary C Sieck
Jun 13, 2009·Journal of Applied Physiology·Heather M ArgadineGary C Sieck
May 23, 2012·Journal of Strength and Conditioning Research·Nathan J HellyerCarlos B Mantilla
Jul 20, 2012·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Sarah M GreisingGary C Sieck
Aug 30, 2014·Journal of Applied Physiology·Carlos B MantillaGary C Sieck
May 3, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarah M GreisingGary C Sieck
Sep 29, 2015·Journal of Neurotrauma·Santiago Alvarez-ArgoteCarlos B Mantilla
May 3, 2018·Journal of Neurophysiology·Joline E BrandenburgGary C Sieck
Nov 28, 2019·Journal of Applied Physiology·Matthew J FogartyGary C Sieck
Apr 1, 1997·Journal of Applied Physiology·W Z ZhanG C Sieck
Nov 25, 2000·Journal of Applied Physiology·B T AmeredesG C Sieck
Feb 26, 2004·Muscle & Nerve·Carlos B MantillaGary C Sieck
Jun 9, 2007·Journal of Applied Physiology·Gary C SieckY S Prakash
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Catherine S H SassoonVincent J Caiozzo
Jan 7, 2010·Biomedical Research·Hidetaka ImagitaHirofumi Miyata
Mar 27, 2015·Muscle & Nerve·Sarah M GreisingCarlos B Mantilla
Nov 11, 2016·Journal of Neurophysiology·Vivian Hernandez-TorresGary C Sieck
Mar 30, 2019·Experimental Physiology·Matthew J FogartyGary C Sieck
Aug 10, 2006·European Journal of Applied Physiology·Menotti Midrio
Feb 19, 2008·The European Journal of Neuroscience·Stéphane VinitAnne Kastner
Nov 5, 2013·The Journal of Physiology·Gary C Sieck, Carlos B Mantilla
Jan 19, 2013·Journal of Applied Physiology·Carlos B Mantilla, Gary C Sieck
Nov 19, 2010·American Journal of Physiology. Cell Physiology·Heather M ArgadineGary C Sieck
Jan 22, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leonid G ErmilovCarlos B Mantilla
Jan 14, 2017·Physiological Reports·Sarah M GreisingCarlos B Mantilla
Nov 4, 2016·The Journal of Comparative Neurology·Heather M GranseeCarlos B Mantilla
Feb 8, 2018·Journal of Neurophysiology·Matthew J FogartyGary C Sieck
Sep 22, 2018·Journal of Applied Physiology·Obaid U KhurramCarlos B Mantilla
Feb 23, 2020·Expert Review of Respiratory Medicine·Matthew J Fogarty, Gary C Sieck
Mar 15, 2001·Journal of Applied Physiology·P C GeigerG C Sieck
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·R Andrew ShanelyScott K Powers
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Catherine S H Sassoon

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