Myopathies in the elderly: a hospital-based study

Neuromuscular Disorders : NMD
Andoni Echaniz-LagunaChristine Tranchant

Abstract

Population in western countries is ageing, and myopathies are likely to be more frequently found in elderly patients. We analyzed the files of 270 consecutive adult patients (age >18 years) with newly diagnosed biopsy-proven myopathy in the 2003-2009 interval. Fifty patients (18%) were aged with more than 70 years. In this group of elderly patients, 50% had inflammatory myopathy, 32% had genetically-determined myopathy, 16% had myopathy of unspecified cause, and 2% had toxic myopathy. When considering muscle weakness and serum creatine kinase activity, there was no statistical difference between elderly patients and younger patients. In contrast, elderly patients more frequently presented with myalgia, inflammatory myopathy, and cancer. Myopathies in the elderly are frequent in developed countries, representing a significant proportion of adult myopathies in our series. Muscle pain was a prominent symptom and inflammatory myopathies, often associated with cancer, were the most frequent cause of myopathy. Clinicians should be aware of the existence of geriatric myopathies, an emerging entity with important implications for management, treatment, and genetic counseling.

References

Sep 28, 2002·Current Opinion in Neurology·Guglielmo Scarlato, Giacomo P Comi
Sep 27, 2003·Lancet·Marinos C Dalakas, Reinhard Hohlfeld
Mar 2, 2006·Muscle & Nerve·Rabi Tawil, Silvère M Van Der Maarel
Jun 24, 2006·Neuromuscular Disorders : NMD·Isabelle Pénisson-BesnierBjarne Udd
Aug 26, 2006·Nature Clinical Practice. Neurology·Marinos C Dalakas
Sep 28, 2007·Neuromuscular Disorders : NMD·Harriet P LoKathryn N North
Jun 26, 2008·Journal of Neurology·Roberta VirgilioGiacomo P Comi
Sep 5, 2008·Current Opinion in Neurology·Caroline A SewryFrancesco Muntoni
Sep 5, 2008·Current Opinion in Neurology·Michela GuglieriHanns Lochmüller
Jul 18, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·M C Dalakas

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Citations

Jun 1, 2014·Skeletal Radiology·Mickaël OhanaRobert-Yves Carlier
Apr 16, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Anthony Chiodo
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri
Jun 27, 2021·BMC Neurology·Fabian HofmeisterMichael Drey
May 12, 2020·Revue neurologique·L ZerahL-L Mariani

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