Myopathy and eosinophilic pneumonia coincidentally induced by treatment with daptomycin

Internal Medicine
Hideharu HagiyaFumio Otsuka

Abstract

A 34-year-old man with 22q11.2 deletion syndrome (DiGeorge syndrome) concurrently suffered from myopathy and eosinophilic pneumonia shortly after receiving daptomycin (DAP) for right-sided infective endocarditis. The simultaneous occurrence of these phenomena in relation to DAP therapy has not been previously well described. An allergic reaction was suspected as a possible etiology of these DAP-related complications. This case highlights the need for close observation in order to detect both musculoskeletal and respiratory disorders from the start of DAP therapy. Physicians should pay more attention to this new drug, which is expected to be frequently used in various clinical settings.

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Citations

Dec 23, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Jun HiraiJiro Fujita
Nov 3, 2017·Internal Medicine·Yoshitsugu HigashiYoshihiro Yamamoto
Dec 22, 2016·Antimicrobial Resistance and Infection Control·Priyasha UppalKristina E Ward

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

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Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

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