PMID: 6167247Mar 1, 1981Paper

Myopathy caused by propoxyphene: report of 2 cases with muscle histochemistry

Arquivos de neuro-psiquiatria
L C WerneckJ C Lozovey

Abstract

The cases of a 43 years old-man with gout and a 24 years-old woman with severe back pain who developed dextro-propoxyphene addiction during pain treatment are reported. They had severe edema and fibrosis of skin, subcutaneous tissue and muscle involving the upper and lower limbs. ESR was elevated, CPK and LDH were normal. EMG in proximal muscles showed decreased duration and voltage of potentials, excess of short polyphasics and increased recruitment (BSAP), with positive waves and fibrillations; distal muscles had fasciculations, fibrillations, positive waves, normal voluntary potentials, decreased recruitment. Lymphography indicate delayed progression of contrast media and obstruction in the thighs. Muscle biopsy on fresh-frozen section and histochemistry showed extensive connective tissue proliferation with intense acid and alkaline phosphatase activity in the perimysial and endomysial area, infiltration of lymphocytes near and around small vessels and capillaries. There were perifascicular and type II fiber atrophy. After discharge the patients returned to propoxyphene addiction and the symptoms who subsided during drug withdrawal come back again. New admission, new drug withdrawal and they were discharged free of symptoms ...Continue Reading

References

Jan 29, 1977·Lancet·V Dubowitz
Feb 12, 1977·Lancet·C H Bowker, P Turmer
Sep 9, 1978·Lancet·R J Lane, F L Mastaglia
Dec 1, 1977·Acta Neurologica Scandinavica·M DamJ Christiansen
Mar 1, 1978·Journal of Neuropathology and Experimental Neurology·N P RosmanJ E Haddow
Oct 1, 1978·Journal of Neurosurgery·A R MacKayP R Weinstein
Jun 1, 1977·Acta Neurologica Scandinavica·O B JensenE Reske-Nielsen
Jul 1, 1977·Annals of Internal Medicine·R S PastanD L Goldenberg
Jul 24, 1976·British Medical Journal·L Wislicki
Jun 28, 1975·British Medical Journal·A Czlonkowska
Jan 1, 1976·Annals of Internal Medicine·J L Holtzman
May 1, 1976·Experimental Neurology·L Wecker, W D Dettbarn
Oct 1, 1972·Neurology·G M FenichelW D Dettbarn
Dec 1, 1973·British Medical Journal·C D MarsdenL Duchen
Jan 1, 1974·Neurology·G M FenichelT M Newman
Oct 1, 1974·Archives of Neurology·E E Serrano, B J Wilder
Oct 10, 1974·The New England Journal of Medicine·W K Engel, D S Zee
Dec 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·M VanhaeverbeekL Franken
Jun 1, 1973·Archives of Neurology·J C SteinerP V De Jesus
Mar 1, 1974·Southern Medical Journal·J B Winfield, K Greer
Nov 27, 1971·British Medical Journal·F L MastagliaP Hudgson
May 1, 1971·The American Journal of Digestive Diseases·N C Klein, M G Magida
Oct 1, 1968·Archives of Neurology·D C AberfeldD Grob
Oct 17, 1968·The New England Journal of Medicine·T Langer, R I Levy
Oct 1, 1969·Archives of Neurology·P W HathawayW K Engel
Oct 8, 1960·Lancet·E D CAMPBELL, E MONTUSCHI
Jan 4, 1962·The New England Journal of Medicine·H A KONTOS

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