Myopathy in the York Platelet Syndrome: An Underrecognized Complication

Case Reports in Pathology
Joy RomanRussell J Butterfield

Abstract

York Platelet Syndrome (YPS) is a calcium channelopathy caused by gain of function in STIM1, a gene which acts as a calcium sensor. It is characterized by platelet abnormalities and muscle weakness. Medical literature emphasizes the hematologic aspects of the cases with few data of the neuromuscular and neuropathologic evaluation. We present a patient with YPS whose myopathy was the most prominent aspect. She presented around 2 years of age with proximal weakness and easy bruisability. YPS was diagnosed in the infant at 16 months of age at the National Institutes of Health. Muscle biopsy demonstrated a severe chronic myopathy. Rimmed vacuoles and tubular aggregates were noted. Although YPS is rare, the combination of a congenital myopathy with thrombocytopenia may facilitate the diagnosis and enable further insights into the disease.

References

Dec 2, 2010·Platelets·James G White, Meral Gunay-Aygun
Jan 13, 2015·Molecular Genetics and Metabolism·Thomas MarkelloMeral Gunay-Aygun
Jan 29, 2015·Molecular Genetics and Metabolism Reports·Amrathlal Rabbind SinghJacques Rochette

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Citations

Aug 20, 2021·Frontiers in Neurology·Li-Jun JiangZan-Hua Rong

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Methods Mentioned

BETA
biopsy
biopsies

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