Myopathy induced by epsilon-aminocaproic acid. Case report

Journal of Neurosurgery
J A BrownS Mullan


The authors present a case of proximal myopathy secondary to epsilon-aminocaproic acid (EACA) administration. This well recognized entity does not occur immediately after institution of therapy, but follows a delay of several days and a cumulative dose. Its consequences include a spectrum of symptoms from myalgias to severe myopathy with rhabdomyolysis, myoglobinuria, and acute tubular necrosis. A presenting symptom of calf pain in a patient receiving EACA should not automatically imply deep vein thrombosis. Serial creatine phosphokinase measurements are essential in monitoring a patient undergoing EACA therapy, especially after 2 weeks of treatment and a total dose of greater than 500 gm.


Jan 1, 1979·Postgraduate Medical Journal·R J LaneF L Mastaglia
Oct 1, 1978·Journal of Neurosurgery·A R MacKayP R Weinstein
Oct 18, 1976·JAMA : the Journal of the American Medical Association·R A RizzaC L Conley
Feb 2, 1974·Lancet·S ErillV Ausina
Aug 1, 1970·Neurology·D D Duane, A G Engel
Apr 13, 1972·The New England Journal of Medicine·M M FrankD W Alling
Jul 1, 1972·Postgraduate Medical Journal·J R Bennett
Dec 1, 1971·Postgraduate Medical Journal·P C Barnes, J H Leonard
Nov 1, 1966·The Medical Clinics of North America·J J Bergin
Feb 2, 1970·JAMA : the Journal of the American Medical Association·D J DrutzW C Hsieh
Jan 1, 1968·Journal of Neurosurgery·S Mullan, J Dawley
Oct 17, 1968·The New England Journal of Medicine·T Langer, R I Levy
May 15, 1969·The New England Journal of Medicine·C Charytan, D Purtilo
May 1, 1980·Muscle & Nerve·C KennardR A Henson
Mar 1, 1981·Muscle & Nerve·C DoriguzziL Palmucci
Mar 1, 1981·Muscle & Nerve·S T Iannaccone, R C Griggs
Mar 1, 1980·Archives of Neurology·C W BrittS S Schochet
Jul 12, 1980·British Medical Journal·C K BiswasP J Tilley
May 1, 1964·Archives of Neurology·K EKBOMK E ASTROM


Dec 1, 1983·Italian Journal of Neurological Sciences·G GalassiA Colombo
Apr 4, 2008·Neurocritical Care·Mark ChwajolE Sander Connolly
Jan 1, 1984·Clinical Neurology and Neurosurgery·D Van RenterghemM Van der Straeten
Dec 1, 1990·Australian and New Zealand Journal of Medicine·J Randall, K Taylor
Mar 1, 1989·Blood Reviews·D Ogston
Jul 1, 1987·British Journal of Urology·B R Johnstone, R R Syme
Oct 1, 1989·Annals of Emergency Medicine·S C CurryD Connor

Methods Mentioned


Related Concepts

Mycotic Aneurysm, Intracranial

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

Postgraduate Medical Journal
R J LaneF L Mastaglia
The New England Journal of Medicine
D Sinclair, C Phillips
© 2021 Meta ULC. All rights reserved