Myopathy induced by epsilon-aminocaproic acid. Case report

Journal of Neurosurgery
J A BrownS Mullan

Abstract

The authors present a case of proximal myopathy secondary to epsilon-aminocaproic acid (EACA) administration. This well recognized entity does not occur immediately after institution of therapy, but follows a delay of several days and a cumulative dose. Its consequences include a spectrum of symptoms from myalgias to severe myopathy with rhabdomyolysis, myoglobinuria, and acute tubular necrosis. A presenting symptom of calf pain in a patient receiving EACA should not automatically imply deep vein thrombosis. Serial creatine phosphokinase measurements are essential in monitoring a patient undergoing EACA therapy, especially after 2 weeks of treatment and a total dose of greater than 500 gm.

References

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Methods Mentioned

BETA
biopsy
ESR
biopsies

Related Concepts

Aminocaproates
Biopsy
Mycotic Aneurysm, Intracranial
Leg
Myopathy
Shoulder
Epsikapron

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