PMID: 45151Dec 1, 1979

Myosin and actin containing cells in the human postnatal thymus. Ultrastructural and immunohistochemical findings in normal thymus and in myasthenia gravis

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
D DrenckhahnU Gröschel-Stewart


Samples of normal human thymus of different ages (4-63 years old) were studied by immunofluorescence microscopy (using antibodies to smooth muscle myosin, to actin from the chicken gizzard, and antibodies to myosin from human striated muscle) as well as by routine electron microscopy. Thymus tissue from myasthenia gravis patients was also investigated for comparative reasons. Epithelial cells reacted with anti-smooth, but not with anti-striated muscle myosin, whereas myoid cells reacted with antibodies to striated, but not to smooth muscle myosin. Both epithelial and myoid cells displayed a strong immunoreactivity with antiactin. Corresponding to this immunoreactivity, both cell types contained bundles of thin, actin-like filaments. Myoid cells occurred in the rounded and elongated variety, and they were a normal constituent of all thymuses investigated in this study. Ultrastructurally, this non-innervated, striated muscle-like cell type possessed bundles of thin and thick filaments as well as Z lines in a rather disorganized arrangement, resembling striated muscle after denervation or various other pathologic conditions. There were no overt differences in the number and structure of myoid cells between healthy and myasthenic p...Continue Reading


Jan 1, 1994·Advances in Neuroimmunology·R Hohlfeld, H Wekerle
Apr 16, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M C RusuA C Didilescu
Jan 1, 1981·Annals of the New York Academy of Sciences·H WekerleI Kalies
Mar 7, 2013·Muscle & Nerve·Andrew McKeonSean J Pittock
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T KirchnerH K Müller-Hermelink
Jan 1, 1988·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T KirchnerH K Müller-Hermelink
Nov 1, 1983·Acta Neurologica Scandinavica·N E GilhusR Matre
Sep 1, 1992·Histopathology·D Suarez VilelaJ R Riera Velasco
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Marino, H K Müller-Hermelink
Jan 15, 2014·Korean Journal of Pathology·Young Keum KimChang Hun Lee
Jul 30, 1999·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A WongJ E Anderson
Apr 21, 2010·Autoimmunity·Rozen Le PanseSonia Berrih-Aknin


Jun 18, 1977·Lancet·E K EngelC L McIntosh
Jan 31, 1978·Cell and Tissue Research·B von Gaudecker
Mar 1, 1978·The Anatomical Record·R M BearmanK G Bensch
Jan 1, 1979·Advances in Experimental Medicine and Biology·B von Gaudecker, H K Müller-Hermelink
Jan 1, 1973·Immunological Communications·J R Tagg, A R McGiven
Apr 2, 1966·Lancet·A J StraussS D Douglas
Mar 23, 1968·Lancet·K Henry
Feb 1, 1972·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaL I Shagal
Jan 1, 1972·The Journal of Pathology·A R Hayward
Nov 1, 1967·The American Journal of Anatomy·E Raviola, G Raviola
Feb 1, 1969·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T ItoK Abe
Oct 17, 1966·JAMA : the Journal of the American Medical Association·R L Van de Velde, N B Friedman

Related Concepts

Immunofluorescence Assay
Neoplasm of Uncertain or Unknown Behavior of Thymus
Squamous Transitional Epithelial Cell Count
Smooth Muscle
Disease of Thymus Gland
Immunofluorescence Microscopy

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.