Myosin diversity in Apicomplexa

The Journal of Parasitology
M B Heintzelman, J D Schwartzman

Abstract

A polymerase chain reaction (PCR) screen was used to examine the diversity of myosins in 7 Apicomplexan parasites: Toxoplasma gondii, Plasmodium falciparum, Neospora caninum, Eimeria tenella, Sarcocystis muris, Babesia bovis, and Cryptosporidium parvum. Using degenerate PCR primers compatible with the majority of known myosin classes, putative myosin sequences were obtained from all of these species. All of the sequences obtained showed greatest similarity to previously identified apicomplexan myosins, suggesting that the diversity of myosins in these parasites is limited. Myosin classes that are known to be widespread across the phylogenetic spectrum, e.g., the myosins I, II, and V, were not seen in the Apicomplexa. Thus, like the plants, the Apicomplexa may have evolved their own unique cohort of myosins that are responsible for the myosin-driven cellular functions observed in these parasites.

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Citations

Nov 6, 2014·Canadian Journal of Microbiology·Marco A VillanuevaRaúl Eduardo Castillo-Medina
Mar 5, 2002·Microbiology and Molecular Biology Reviews : MMBR·Naomi S Morrissette, L David Sibley
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bernardo J FothDominique Soldati
Mar 21, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jürgen BoschWim G J Hol
Jul 12, 2002·Cell Motility and the Cytoskeleton·A E LewJ C Pinder
Mar 24, 2004·Current Opinion in Cell Biology·Dominique Soldati, Markus Meissner
Apr 1, 2008·The Journal of Parasitology·Matthew B Heintzelman, Marcus J Mateer
Apr 27, 2010·Medical Microbiology and Immunology·Andrea KuehnGabriele Pradel
Mar 2, 2011·Journal of Computer-aided Molecular Design·Sandhya KortagereWilliam J Welsh
Oct 17, 2002·The Anatomical Record·Reid F Thompson, George M Langford
Nov 30, 2005·The Journal of Eukaryotic Microbiology·Terence M Preston, Conrad A King
Sep 9, 2011·Cellular Microbiology·Inga Siden-KiamosKai Matuschewski
Oct 10, 2006·Molecular and Biochemical Parasitology·Inga Siden-KiamosChristos Louis
Aug 30, 2020·International Journal of Molecular Sciences·Zill E AnamShailja Singh
Oct 4, 2017·The Journal of Biological Chemistry·Cameron J PowellMartin J Boulanger

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Methods Mentioned

BETA
PCR

Software Mentioned

BLAST

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