PMID: 8596693Feb 1, 1996Paper

Myosin heavy chain isoform transformation in single fibres from m. vastus lateralis in spinal cord injured individuals: effects of long-term functional electrical stimulation (FES)

Pflügers Archiv : European journal of physiology
J L AndersenMichael Kjaer

Abstract

The myosin heavy chain (MHC) composition of single fibres from m. vastus lateralis of five spinal- cord-injured (SCI) individuals was analysed by Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) before, and after 6 and 12 months of functional electrical stimulation (FES)-training, administrated for 30 min three times per week. Prior to FES training 37.2% of the fibres contained only MHC IIB, 21.2% only MHC IIA, and 40.7% co-expressed MHC IIA and MHC IIB. After 6 months of FES-training the number of fibres containing only MHC IIB was reduced to 2.6% (P < 0.05), the number of fibres containing only MHC IIA was increased to 44.3% (P < 0.05), and the number of fibres co-expressing MHC IIA and MHC IIB was 50.9% (ns). After 12 months almost all fibres (91.2%, P < 0.05) contained only MHC IIA. The number of fibres containing only MHC IIB was 2.3% and the fibres co-expressing MHC IIA and IIB had decreased to 4.6% (P < 0.05). The amount of fibres containing only MHC I never exceeded 0.5%. Likewise, the number of fibres co-expressing MHC I and MHC IIA was below 2% throughout the study period. In total, the MHC composition of 1596 single fibres was determined. This study shows that FES-training of paralysed human skel...Continue Reading

References

Sep 1, 1976·Scandinavian Journal of Clinical and Laboratory Investigation·N D Poe
Apr 1, 1992·Journal of Applied Physiology·R B SteinM Belanger
Jan 1, 1992·Reviews of Physiology, Biochemistry and Pharmacology·D Pette, G Vrbová
Sep 1, 1990·Acta Physiologica Scandinavica·H KlitgaardB Saltin
Oct 1, 1985·Muscle & Nerve·D Pette, G Vrbová
Dec 1, 1994·The American Journal of Physiology·V SmerduS Schiaffino
Apr 1, 1995·Journal of Applied Physiology·R J TalmadgeV R Edgerton
Feb 1, 1995·Journal of Muscle Research and Cell Motility·S EnnionG Goldspink
Dec 1, 1993·Paraplegia·J M GreveL R Batisttella
Nov 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R S Staron, P Johnson
Jun 1, 1993·Journal of the Neurological Sciences·J M RoundD A Jones
Feb 1, 1993·Journal of Applied Physiology·G R AdamsG A Dudley

❮ Previous
Next ❯

Citations

Nov 24, 1999·Muscle & Nerve·A HartkoppF Biering-Sørensen
May 8, 2008·European Journal of Applied Physiology·Nikolaos KesidisKonstantinos Mandroukas
Feb 19, 2009·European Journal of Applied Physiology·Todd Anthony Astorino, Eric T Harness
Nov 1, 2011·European Journal of Applied Physiology·Sebastian GehlertWilhelm Bloch
Jun 12, 2013·Cell and Tissue Research·Vigdis AasArild C Rustan
Apr 23, 2013·Archives of Physical Medicine and Rehabilitation·Rob LabruyèreHubertus J van Hedel
Mar 7, 2009·Research in Sports Medicine·Michael J McKenzieCharlene E Hafer-Macko
Oct 26, 2000·British Journal of Sports Medicine·M Kjaer
Oct 26, 2000·British Journal of Sports Medicine·T B Price
Apr 26, 2008·Journal of Applied Physiology·Shauna Dudley-JavoroskiRichard K Shields
Jan 13, 2006·Journal of Neurophysiology·Richard K Shields, Shauna Dudley-Javoroski
Sep 23, 2003·American Journal of Respiratory and Critical Care Medicine·Russell S RichardsonPeter D Wagner
Feb 22, 2007·Neurorehabilitation and Neural Repair·Richard K Shields, Shauna Dudley-Javoroski
Jun 21, 2008·Journal of Rehabilitation Research and Development·Shauna Dudley-Javoroski, Richard K Shields
Jul 10, 2010·European Journal of Applied Physiology·M V Narici, M D de Boer
Feb 5, 2016·Journal of Muscle Research and Cell Motility·Kevin A MurachAndrew J Galpin
Aug 14, 2012·Experimental Gerontology·Fennigje M Purves-SmithRussell T Hepple
Mar 9, 2010·Revue des maladies respiratoires·A Couillard, C Prefaut
Apr 1, 2010·Biomedical Signal Processing and Control·Zhijun CaiRichard K Shields
Mar 1, 2009·Automatica : the Journal of IFAC, the International Federation of Automatic Control·Er-Wei BaiRichard K Shields
Jul 17, 2007·Experimental Physiology·Stephen D R Harridge
Jul 22, 2008·Muscle & Nerve·Kirsten Legerlotz, Heather K Smith
Sep 25, 2010·Scandinavian Journal of Medicine & Science in Sports·J L Andersen, P Aagaard
Feb 12, 2005·Archives of Physical Medicine and Rehabilitation·Chad C CarrollScott W Trappe
Feb 3, 2012·Clinical Neurology and Neurosurgery·Mary P Galea
Jun 2, 2001·Archives of Physical Medicine and Rehabilitation·H L GerritsM T Hopman
Mar 8, 2016·Cells, Tissues, Organs·J A M KorfageG E J Langenbach
Dec 25, 2003·Muscle & Nerve·Regina M CrameriAdele Weston
Jan 7, 2017·Journal of Applied Physiology·Gwénaëlle BegueScott Trappe
May 8, 2002·Muscle & Nerve·Stephen D R HarridgeMichael Kjaer
Jul 22, 2004·Muscle & Nerve·Patrick G De DeyneRichard F Macko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.