PMID: 8964738Mar 1, 1996Paper

Myosin heavy chain of immature soleus muscle grafts adapts to hyperthyroidism more than to physical activity

Journal of Applied Physiology
S T Devor, T P White

Abstract

The interaction of hyperthyroidism and the elements of physical activity on early regeneration of muscle grafts was investigated. Soleus muscle grafts were studied 15 days after graft operations in eu- and hyperthyroid rats. Hypotheses were tested regarding the adaptation of the myosin heavy chain (MHC) profile of grafts and nongrafted control muscles and whether the effect of hyperthyroidism would predominate over the opposing influence of recruitment and mechanical load on MHC of grafts. Denervation and myectomy of synergist muscles were employed to manipulate the elements of physical activity. Denervation decreased the expression of type I MHC, and hyperthyroidism furthered the shift toward a "fast" isoform profile. For example, in denervated grafts, type IIb was undetected in euthyroid rats and accounted for 31% of MHC in hyperthyroid rats. Compared with control muscles, grafts in the denervated and innervated-normal load groups demonstrated greater plasticity because the adaptive response of MHC to thyroid status was more pronounced. Hyperthyroidism predominated over the opposing influence of the elements of physical activity on the regulation of MHC expression in innervated plus overload grafts. For example, type I MHC wa...Continue Reading

Citations

Mar 25, 1999·Acta Physiologica Scandinavica·A X BigardA d'Albis
Feb 7, 2001·American Journal of Physiology. Cell Physiology·V J CaiozzoK M Baldwin
Oct 16, 2001·American Journal of Physiology. Cell Physiology·A X BigardR Ventura-Clapier
Sep 10, 2003·Journal of Applied Physiology·Craig O MatternSteven T Devor
Dec 20, 2005·Journal of Muscle Research and Cell Motility·Philippe NoirezArnaud Ferry
Jun 8, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M O BoluytT P White

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