PMID: 9538937Apr 16, 1998Paper

Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits

Basic Research in Cardiology
D M EbleF G Spinale

Abstract

Chronic tachycardia causes LV dilatation and dysfunction, with no hypertrophy. However, the contributing mechanisms responsible for the left ventricular (LV) remodeling in the absence of myocardial growth in this model of heart failure remain unclear. Therefore, the goal of the present study was to serially examine changes in LV function, steady state myosin heavy chain (MHC) mRNA levels, in vivo synthesis rates, and abundance with the progression of chronic tachycardia induced heart failure. Adult rabbits (3.5-4.5 kg) were studied after one, two, or three weeks of pacing ventricular tachycardia (VT; 400 bpm) and in controls (n = 6 for all groups). LV fractional shortening was reduced by 30% at week one and by over 50% at week three of chronic VT. End-diastolic dimension (EDD) increased at week two compared to controls (1.66 +/- 0.10 vs 1.35 +/- 0.11 cm, p < 0.05) and increased further at week three of VT (1.70 +/- 0.06 cm, p < 0.05). The progressive changes in LV geometry and function with chronic VT were not associated with concomitant time dependent changes in LV mass or MHC mRNA levels. In contrast, MHC fractional synthesis rates increased and reached statistical significance at week three of VT compared to controls (8.3 +/...Continue Reading

Citations

Jan 11, 2001·Journal of Pharmacological and Toxicological Methods·A H SmithD R Knight
Aug 15, 2009·Cardiovascular Research·Daniel GrosMatteo E Mangoni
Jun 11, 2004·Genome Génome / Conseil National De Recherches Canada·Olga V Anatskaya, Alexander E Vinogradov
Mar 16, 2011·Journal of Biomedicine & Biotechnology·Carlos ZaragozaJesus Egido
Aug 4, 2012·Journal of Cardiac Failure·Christoph BirnerAndreas Luchner

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