Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia

Journal of Leukocyte Biology
Eric J WigtonJordan Jacobelli

Abstract

Leukemia dissemination (the spread of leukemia cells from the bone marrow) and relapse are associated with poor prognosis. Often, relapse occurs in peripheral organs, such as the CNS, which acts as a sanctuary site for leukemia cells to escape anti-cancer treatments. Similar to normal leukocyte migration, leukemia dissemination entails migration of cells from the blood circulation into tissues by extravasation. To extravasate, leukemia cells cross through vascular endothelial walls via a process called transendothelial migration, which requires cytoskeletal remodeling. However, the specific molecular players in leukemia extravasation are not fully known. We examined the role of myosin-IIA a cytoskeletal class II myosin motor protein, in leukemia progression and dissemination into the CNS by use of a mouse model of Bcr-Abl-driven B cell acute lymphoblastic leukemia. Small hairpin RNA-mediated depletion of myosin-IIA did not affect apoptosis or the growth rate of B cell acute lymphoblastic leukemia cells. However, in an in vivo leukemia transfer model, myosin-IIA depletion slowed leukemia progression and prolonged survival, in part, by reducing the ability of B cell acute lymphoblastic leukemia cells to engraft efficiently. Final...Continue Reading

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Citations

Feb 1, 2019·Journal of Leukocyte Biology·Ichiko KinjyoBridget S Wilson
Dec 8, 2019·Proceedings of the National Academy of Sciences of the United States of America·Eduardo VadilloMichael Schnoor
Dec 11, 2019·Cancer Metastasis Reviews·Fen ZhouHongbo Chen
May 12, 2017·Frontiers in Pediatrics·Nathan P Gossai, Peter M Gordon
Jul 14, 2020·International Journal of Hematology·Syahrul ChilmiKazuhiro Morishita
May 20, 2020·International Journal of Molecular Sciences·Fengjiao ChangKyungpyo Park
Mar 7, 2021·Cancers·Nayden G NaydenovAndrei I Ivanov
May 1, 2021·International Journal of Molecular Sciences·Erica DanderGiovanni Cazzaniga
Jun 8, 2018·Journal of Medicinal Chemistry·Bart I RomanChristian V Stevens

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