Myosin isoforms and functional diversity in vertebrate smooth muscle

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
R A MurphyJ D Strauss

Abstract

The expression of fast and slow myosin isoforms in individual cells is associated with differences in shortening velocities and power output in fully differentiated vertebrate striated muscle. This paradigm in which shortening velocity is determined by the myosin isoform (and load) is inappropriate for smooth muscle. Smooth muscle tissues express multiple myosin heavy and light chain isoforms, and it is not currently possible to separate and identify chemically distinct native myosin hexamers (i.e., isoforms). It is not known if different isoforms are localized in subpopulations of cells or in specific cellular domains nor whether they combine preferentially to form a small number of native myosin hexamer isoforms. Potentially, thick filaments are aggregates of many different combinations of heavy and light chain isoforms that may or may not exhibit different kinetics. Shortening velocities in smooth muscle are regulated by Ca(2+)-dependent crossbridge phosphorylation of the myosin regulatory light chains. Much of the observed diversity in power output in smooth muscle may be attributed to regulatory mechanisms modulating crossbridge cycling rates rather than contractile protein isoform expression.

References

May 1, 1992·Journal of Hypertension·I L Morano
Jun 1, 1992·Journal of Biochemistry·Y Hasegawa, F Morita
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T KitazawaA P Somlyo
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·A M ZanellatoS Sartore
Jan 1, 1991·Advances in Experimental Medicine and Biology·M IkebeS Maruta
Jan 1, 1991·Cell Motility and the Cytoskeleton·K M Trybus
Jul 1, 1991·Pflügers Archiv : European journal of physiology·U Malmqvist, A Arner
Jul 1, 1991·The American Journal of Physiology·C M Rembold
May 1, 1991·The American Journal of Physiology·D E Harris, D M Warshaw
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P BabijM Periasamy
Feb 28, 1991·Biochemical and Biophysical Research Communications·M FasoloL Dalla Libera
Jun 1, 1991·The American Journal of Physiology·J S DrewR A Murphy
Aug 1, 1990·The American Journal of Physiology·G J KargacinF S Fay
Sep 1, 1990·Pflügers Archiv : European journal of physiology·B HimpensA P Somlyo
Sep 1, 1990·Experimental Cell Research·A C BorrioneS Sartore
Nov 15, 1990·Biochemical and Biophysical Research Communications·T Kitazawa, A P Somlyo
Aug 1, 1990·Pflügers Archiv : European journal of physiology·F V BrozovichK G Morgan
Aug 1, 1990·The American Journal of Physiology·C M Rembold, R A Murphy
Dec 1, 1989·The Journal of Cell Biology·K M Trybus
Nov 1, 1989·The American Journal of Physiology·B D GaylinnR A Murphy
Jan 1, 1989·Annual Review of Physiology·R J Paul
Jan 1, 1988·The American Journal of Physiology·C M Hai, R A Murphy
Jan 1, 1988·Journal of Biochemistry·Y HasegawaF Morita
Jul 1, 1988·The American Journal of Physiology·C M Hai, R A Murphy
Jan 1, 1986·The Journal of Cell Biology·J V SmallJ De Mey
Sep 1, 1986·The American Journal of Physiology·H A SingerR A Murphy
Jul 1, 1985·The American Journal of Physiology·N W Weisbrodt, R A Murphy
Jul 1, 1967·The Journal of General Physiology·M Bárány
Jan 1, 1971·Angiologica·D F Bohr, R L Verrier
Jan 1, 1971·Physiological Reviews·J C Rüegg
Jun 1, 1983·Journal of Muscle Research and Cell Motility·R A Podolin, L E Ford
Mar 1, 1983·The American Journal of Physiology·W T Gerthoffer, R A Murphy
Mar 1, 1983·Journal of Biochemistry·H Takano-OhmuroT Masaki

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Citations

Sep 12, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·T J Eddinger
Sep 12, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G C SieckK A Jones
Nov 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mei ChiMuthu Periasamy
Sep 8, 2007·Canadian Journal of Physiology and Pharmacology·Steven S An, Jeffrey J Fredberg
Apr 16, 2004·Respiratory Research·Jeffrey J Fredberg
Oct 8, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Mei ChiMuthu Periasamy
Feb 26, 2000·In Vitro Cellular & Developmental Biology. Animal·K M CrossC W Bowers
Jul 8, 2005·American Journal of Physiology. Cell Physiology·Renaud LéguilletteAnne-Marie Lauzon
May 4, 2007·American Journal of Physiology. Cell Physiology·Thomas J Eddinger, Daniel P Meer
Jan 10, 2002·The Journal of Cell Biology·Arthur S RovnerKathleen M Trybus
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chi-Ming HaiBarbara S Stonestreet
Feb 24, 2001·American Journal of Physiology. Cell Physiology·T J Eddinger, D P Meer
Jun 6, 2000·American Journal of Physiology. Cell Physiology·T J EddingerJ J Sherwood

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