Myosin motor function: the ins and outs of actin-based membrane protrusions.

Cellular and Molecular Life Sciences : CMLS
Rajalakshmi NambiarMatthew J Tyska

Abstract

Cells build plasma membrane protrusions supported by parallel bundles of F-actin to enable a wide variety of biological functions, ranging from motility to host defense. Filopodia, microvilli and stereocilia are three such protrusions that have been the focus of intense biological and biophysical investigation in recent years. While it is evident that actin dynamics play a significant role in the formation of these organelles, members of the myosin superfamily have also been implicated as key players in the maintenance of protrusion architecture and function. Based on a simple analysis of the physical forces that control protrusion formation and morphology, as well as our review of available data, we propose that myosins play two general roles within these structures: (1) as cargo transporters to move critical regulatory components toward distal tips and (2) as mediators of membrane-cytoskeleton adhesion.

References

May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A Bretscher, K Weber
Jun 1, 1979·Biophysical Journal·D P Corey, A J Hudspeth
Aug 1, 1990·The Journal of Cell Biology·S M HaydenM S Mooseker
Oct 5, 1989·Nature·A J Hudspeth
Nov 1, 1973·Zeitschrift Für Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie·W Helfrich
Jul 1, 1980·The Journal of Cell Biology·L G TilneyM J Mulroy
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B Goldberg, J A Theriot
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·W M BementM S Mooseker
Jul 1, 1993·Biophysical Journal·C S PeskinG F Oster
Feb 25, 1993·Nature·R W DavenportS B Kater
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K G KozminskiJ L Rosenbaum
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·T Q UyedaJ A Spudich
Jan 1, 1995·Annual Review of Cell and Developmental Biology·J A Theriot
Jan 1, 1996·Biophysical Journal·F M HochmuthM P Sheetz
Oct 25, 1996·Journal of Molecular Biology·R YasudaK Kinosita
Dec 1, 1996·Biophysical Journal·A Mogilner, G Oster
Jun 16, 1997·The Journal of Cell Biology·T HassonD P Corey
Jan 1, 1997·Cell Motility and the Cytoskeleton·T HassonK P Steel
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·H MiyataK Kinosita
Jun 11, 1999·Journal of Cellular Physiology·K Lange
Sep 3, 1999·Journal of Muscle Research and Cell Motility·M J Redowicz
Oct 20, 1999·Developmental Biology·T SelfK P Steel
Dec 10, 1999·Biophysical Journal·J Dai, M P Sheetz
Aug 11, 2000·Genomics·A C Dosé, B Burnside
Aug 18, 2000·The Journal of Biological Chemistry·D M WarshawK M Trybus
Sep 21, 2000·American Journal of Physiology. Renal Physiology·P GuoS Weinbaum
Feb 24, 2001·Traffic·J A Theriot
Mar 27, 2001·Current Biology : CB·R I TuxworthM A Titus
Apr 11, 2001·Molecular Biology of the Cell·J S BergR E Cheney
May 2, 2001·Nature Reviews. Molecular Cell Biology·M P Sheetz

❮ Previous
Next ❯

Citations

Aug 16, 2011·Nano Letters·Martin StreichfussJoachim P Spatz
Jan 10, 2013·Nature Reviews. Molecular Cell Biology·David S Gokhin, Velia M Fowler
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dina FinanJames A Spudich
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gordian SchudtStephan Becker
Mar 1, 2012·The Journal of Biological Chemistry·Jessica N Mazerik, Matthew J Tyska
Oct 12, 2012·Molecular Biology of the Cell·Libera Lo PrestiSophie G Martin
Jun 19, 2013·Molecular Biology and Evolution·Arnau Sebé-PedrósIñaki Ruiz-Trillo
Nov 30, 2011·Journal of Cell Science·Michael L Kerber, Richard E Cheney
May 9, 2012·Journal of Cell Science·M Amanda Hartman, James A Spudich
May 17, 2011·PLoS Computational Biology·Doron KabasoNir S Gov
Jun 7, 2011·Annual Review of Cell and Developmental Biology·M Amanda HartmanJames A Spudich
Jun 5, 2012·Free Radical Biology & Medicine·Flávia Figueiredo de RezendeJohannes A Eble
May 5, 2011·Developmental Neurobiology·Hongai Xia, Donald F Ready
Jul 22, 2015·The Journal of Cell Biology·Marie-Thérèse ProspériEvelyne Coudrier
Apr 16, 2013·Biochemical and Biophysical Research Communications·Raman Deep SinghRichard E Pagano
Nov 26, 2014·The Journal of Cell Biology·Scott W CrawleyMatthew J Tyska
Oct 12, 2010·Cell Adhesion & Migration·Horace M DeLisser
Oct 7, 2011·Cell Adhesion & Migration·Antti ArjonenJohanna Ivaska
Feb 6, 2015·Human Molecular Genetics·Misato YoshikawaJin-ichi Inokuchi
Jul 5, 2011·Biophysical Journal·Yujie Sun, Yale E Goldman
May 3, 2016·The Journal of Physical Chemistry. B·Jason A Wagoner, Ken A Dill
May 27, 2017·Journal of Cellular Physiology·Facundo M TonucciMaria C Larocca
May 14, 2016·Journal of Cell Science·Raphael CourjaretKhaled Machaca
Jan 24, 2019·Médecine sciences : M/S·Evelyne Coudrier, Olga Iuliano
Aug 26, 2014·EMBO Reports·Jean-Baptiste CoutelisStéphane Noselli
Dec 19, 2019·Genome Biology and Evolution·Victoria ShabardinaWojciech Makalowski
Dec 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dario Saczko-BrackClaudia Veigel
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jianchao LiMingjie Zhang
Mar 29, 2018·The Journal of Cell Biology·Olga IulianoEvelyne Coudrier
Jul 15, 2017·Bulletin of Mathematical Biology·Cole ZmurchokLeah Edelstein-Keshet
Mar 6, 2018·Frontiers in Cell and Developmental Biology·Dacheng Liang
Apr 8, 2017·Physical Review Letters·Isabella R Graf, Erwin Frey
Apr 11, 2020·International Journal of Molecular Sciences·A Navinés-Ferrer, M Martín

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Trends in Cell Biology
Russell E McConnell, Matthew J Tyska
Current Opinion in Cell Biology
Jan Faix, Klemens Rottner
Nature Reviews. Molecular Cell Biology
Pieta K Mattila, Pekka Lappalainen
Cellular and Molecular Life Sciences : CMLS
Kathleen M Trybus
© 2021 Meta ULC. All rights reserved