Nov 15, 2001

Myosin VI is a processive motor with a large step size

Proceedings of the National Academy of Sciences of the United States of America
R S RockH L Sweeney

Abstract

Myosin VI is a molecular motor involved in intracellular vesicle and organelle transport. To carry out its cellular functions myosin VI moves toward the pointed end of actin, backward in relation to all other characterized myosins. Myosin V, a motor that moves toward the barbed end of actin, is processive, undergoing multiple catalytic cycles and mechanical advances before it releases from actin. Here we show that myosin VI is also processive by using single molecule motility and optical trapping experiments. Remarkably, myosin VI takes much larger steps than expected, based on a simple lever-arm mechanism, for a myosin with only one light chain in the lever-arm domain. Unlike other characterized myosins, myosin VI stepping is highly irregular with a broad distribution of step sizes.

  • References29
  • Citations227

Citations

Mentioned in this Paper

Minus End of Actin Filament
Myosin Type V
Gait, Drop Foot
Chimeric Proteins, Recombinant
Cell Motility
Isoactin
Actins
Protoplasm
Motility Proteins
Plus End of Actin Filament

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