Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry

Nature Communications
Thomas JuanMaximilian Fürthauer

Abstract

The establishment of left-right (LR) asymmetry is fundamental to animal development, but the identification of a unifying mechanism establishing laterality across different phyla has remained elusive. A cilia-driven, directional fluid flow is important for symmetry breaking in numerous vertebrates, including zebrafish. Alternatively, LR asymmetry can be established independently of cilia, notably through the intrinsic chirality of the acto-myosin cytoskeleton. Here, we show that Myosin1D (Myo1D), a previously identified regulator of Drosophila LR asymmetry, is essential for the formation and function of the zebrafish LR organizer (LRO), Kupffer's vesicle (KV). Myo1D controls the orientation of LRO cilia and interacts functionally with the planar cell polarity (PCP) pathway component VanGogh-like2 (Vangl2), to shape a productive LRO flow. Our findings identify Myo1D as an evolutionarily conserved regulator of animal LR asymmetry, and show that functional interactions between Myo1D and PCP are central to the establishment of animal LR asymmetry.

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Citations

Nov 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Poulomi RayLeo Q Wan
Jan 10, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruikun HuYing Cao
Aug 17, 2019·Development·Daniel T Grimes
Apr 24, 2020·PLoS Genetics·Anil ChouguleStéphane Noselli
Jun 10, 2020·PloS One·Anshuman SewdaUNKNOWN Pediatric Cardiac Genomics Consortium
Aug 25, 2018·Nature Communications·Manush SaydmohammedMichael Tsang
Feb 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Takeshi A OnumaHiroki Nishida
Nov 24, 2018·Development·Audrey DesgrangeSigolène M Meilhac
Mar 10, 2020·F1000Research·Hiroshi Hamada, Patrick Tam
Nov 10, 2020·The International Journal of Biochemistry & Cell Biology·Lena BrückerHelen Louise May-Simera
May 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Teije C MiddelkoopStephan W Grill
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Laura Maeso-AlonsoMaria C Marin
Nov 24, 2021·The Journal of Cell Biology·Xiao-Lin ShenHui-Yan Li

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Methods Mentioned

BETA
transgenic
in vitro transcription
PCR
PCRs
genotyping

Software Mentioned

Ensembl
ImageJ MTrackJ
ImageJ
MTrackJ

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