Myositis autoantibody profiles and their clinical associations in Greek patients with inflammatory myopathies

Clinical Rheumatology
Evangelia ZampeliHaralampos M Moutsopoulos

Abstract

Myositis-specific (MSAs) or-associated autoantibodies (MAAs) have been linked to particular clinical phenotypes of idiopathic inflammatory myopathies (IIM) and appear to aid diagnosis. The objective of this study was to analyze the prevalence of MSAs and MAAs and their possible clinical associations in Greek IIM patients. This study comprised 95 IIM patients classified based on the 2017 EULAR/ACR classification criteria. All patients had MSAs and MAAs measured in their sera by line immunoblot assay. Dermatomyositis was the most prevalent IIM clinical subtype. MSAs were found in 44% of the patients, whereas MAAs in 23%. The most frequently detected MSA was anti-Jo-1 (22%), while the most frequently detected MAA was anti-Ro-52 (30%). The distributions of MSAs/MAAs did not differ between the five IIM subgroups, except for anti-Mi-2 which was only detected in dermatomyositis patients. Patients with at least one MSA and/or MAA positivity showed more frequently IIM characteristic skin rashes, while those presenting solely MAA positivity had more often puffy hands and Raynaud's phenomenon. Anti-Jo1-positive patients presented more frequently lung disease, while anti-Ro52 positivity related to mechanic's hands. Anti-Ro-52 and anti-Jo-1...Continue Reading

References

Feb 20, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Nov 21, 1991·The New England Journal of Medicine·M C Dalakas
Feb 9, 2000·Annals of the Rheumatic Diseases·G J HengstmanB G van Engelen
Jan 13, 2001·Annals of the Rheumatic Diseases·R BrouwerW J van Venrooij
Sep 27, 2003·Lancet·Marinos C Dalakas, Reinhard Hohlfeld
Mar 17, 2009·Autoimmunity Reviews·Johan RönnelidIngrid E Lundberg
Sep 5, 2009·Current Opinion in Rheumatology·Katalin DankóTamás Constantin
Oct 12, 2011·Arthritis and Rheumatism·Manabu FujimotoKazuhiko Takehara
Jan 13, 2012·Arthritis and Rheumatism·Minoru SatohFrederick W Miller
Oct 2, 2015·Clinical Reviews in Allergy & Immunology·Minoru SatohEdward K L Chan
Oct 11, 2015·Clinical Reviews in Allergy & Immunology·Harsha Gunawardena
Nov 26, 2015·Journal of Internal Medicine·Z Betteridge, N McHugh
May 20, 2016·Rheumatology International·Puja SrivastavaRamnath Misra
Sep 1, 2017·Annals of the Rheumatic Diseases·James B LillekerUNKNOWN all EuroMyositis contributors
Oct 29, 2017·Annals of the Rheumatic Diseases·Ingrid E LundbergUNKNOWN International Myositis Classification Criteria Project consortium, The Euromyositis register and The Juvenile Dermatomyositi
Jan 27, 2018·Annals of the Rheumatic Diseases·Jean-Baptiste VulstekeXavier Bossuyt
Mar 16, 2018·Clinical and Molecular Allergy : CMA·Boaz PaltererPaola Parronchi

❮ Previous
Next ❯

Citations

May 17, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Evangelia Zampeli, Haralampos M Moutsopoulos
Jul 14, 2020·Current Opinion in Pulmonary Medicine·Toyoshi Yanagihara, Yoshikazu Inoue
Oct 12, 2019·Advances in Rheumatology·Fernando Henrique Carlos de SouzaSamuel Katsuyuki Shinjo
Jan 16, 2021·Acta Clinica Belgica·Stefan Van CauwelaertRogier Nieuwendijk
Mar 29, 2021·ACR Open Rheumatology·Jemima AlbaydaLisa Christopher-Stine
May 11, 2021·Frontiers in Immunology·Andrea Aguilar-VazquezMonica Vazquez-Del Mercado
Nov 13, 2021·Critical Reviews in Clinical Laboratory Sciences·Konstantinos I TsamisIoannis Sarmas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Rheumatic Diseases Clinics of North America
I N Targoff
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Jan Tore GranDavid Scheie
© 2022 Meta ULC. All rights reserved