Myositis, rhabdomyolysis and severe hypercalcaemia in a body builder

Endocrinology, Diabetes & Metabolism Case Reports
Ravikumar RavindranMohamed Adlan

Abstract

A 53-year-old man who used growth hormone (GH), anabolic steroids and testosterone (T) for over 20 years presented with severe constipation and hypercalcaemia. He had benign prostatic hyperplasia and renal stones but no significant family history. Investigations showed - (1) corrected calcium (reference range) 3.66 mmol/L (2.2-2.6), phosphate 1.39 mmol/L (0.80-1.50), and PTH 2 pmol/L (1.6-7.2); (2) urea 21.9 mmol/L (2.5-7.8), creatinine 319 mmol/L (58-110), eGFR 18 mL/min (>90), and urine analysis (protein 4+, glucose 4+, red cells 2+); (3) creatine kinase 7952 U/L (40-320), positive anti Jo-1, and Ro-52 antibodies; (4) vitamin D 46 nmol/L (30-50), vitamin D3 29 pmol/L (55-139), vitamin A 4.65 mmol/L (1.10-2.60), and normal protein electrophoresis; (5) normal CT thorax, abdomen and pelvis and MRI of muscles showed 'inflammation', myositis and calcification; (6) biopsy of thigh muscles showed active myositis, chronic myopathic changes and mineral deposition and of the kidneys showed positive CD3 and CD45, focal segmental glomerulosclerosis and hypercalcaemic tubular changes; and (7) echocardiography showed left ventricular hypertrophy (likely medications and myositis contributing), aortic stenosis and an ejection fraction of 44%...Continue Reading

Citations

Jun 19, 2021·Frontiers in Pharmacology·Chun-Ping LiuHong-Xing Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
electrophoresis

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Irish Journal of Medical Science
B Keogh
Clinical Medicine : Journal of the Royal College of Physicians of London
P C Selby
Progress in Clinical and Biological Research
G D Chisholm
The Journal of the Association of Physicians of India
G SuhasiniP S Menon
Clinical Endocrinology
T J Martin, V Grill
© 2021 Meta ULC. All rights reserved