PMID: 6989350May 1, 1980Paper

Myospherulosis: a preventable iatrogenic nasal and paranasal entity

Archives of Otolaryngology
T M WheelerM H McGavran


We discuss a disorder that, although at first considered of possible fungal origin, now is known to be due to an alteration of erythrocytes induced by petrolatum-based antibiotic ointment. In this country, the structures of myospherulosis have been seen most often in tissues from the nose and paranasal sinuses following surgery in this region. Our studies show that both components of the vehicle of a commonly used tetracycline antibiotic ointment, lanolin and petrolatum, either separately or together, produce the structures of myospherulosis in vitro. It is recommended that a nonpetrolatum-based substance be used in nasal packing for purposes of hemostasis.


Jan 30, 2004·Journal of Clinical Pathology·P C W LuiC H Choi
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Feb 1, 1984·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A R Gould, J J Mascaro
Mar 5, 1998·Journal of the American Academy of Dermatology·J W Patterson, G A Kannon
Jun 29, 2015·Otolaryngologic Clinics of North America·James R Martin, Monica O Patadia
Jun 14, 2000·The Laryngoscope·Y H Goh, R L Goode
Apr 29, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·C FlagothierP Quatresooz
Apr 13, 2007·American Journal of Clinical Dermatology·Pascale Quatresooz, Gérald E Piérard
Jul 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D R Paugh, M J Sullivan
May 1, 1988·Medical Toxicology and Adverse Drug Experience·L K GolightlyB H Rumack
May 1, 1997·American Journal of Rhinology·T S SheenY H Hsu

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