Myostatin expression in muscular dystrophies and mitochondrial encephalomyopathies

Pediatric Neurology
Manuel Castro-GagoJesús Devesa

Abstract

The demonstration that myostatin may negatively regulate muscle mass in adult individuals has raised the possibility of targeting the myostatin pathway in order to increase muscle growth in a variety of muscle degenerative and wasting conditions. In this regard, blockade of endogenous myostatin results in anatomic, biochemical, and physiologic improvement in the dystrophic phenotype in the mdx mouse. Moreover, myostatin messenger ribonucleic acid levels are decreased in the regenerated muscle of these mice, suggesting that myostatin may also be involved in the pathogenesis of the disease. To gain further insight into the possible role of myostatin in muscle degenerative diseases, the present work investigates the expression of muscle myostatin in children with muscular dystrophies and mitochondrial encephalomyopathies. No differences in the pattern of myostatin expression were evident in any case, even in those patients with prominent muscular atrophy. These findings suggest that muscle loss that can be observed in muscle degenerative diseases does not depend on changes in myostatin expression.

References

Apr 10, 2002·American Journal of Physiology. Cell Physiology·Ramón RíosJesús Devesa
Jul 23, 2002·Journal of Applied Physiology·B S TsengF W Booth
Dec 16, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sasha BogdanovichTejvir S Khurana
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·G MilanR Vettor
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Se-Jin Lee
Nov 24, 2004·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rocco BarazzoniGianfranco Guarnieri
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sasha BogdanovichTejvir S Khurana

❮ Previous
Next ❯

Citations

Apr 5, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Adam P Sharples, Claire E Stewart
Sep 26, 2006·Pediatric Neurology·Chad Markert, Martin K Childers
Sep 16, 2014·Frontiers in Aging Neuroscience·Kunihiro SakumaAkihiko Yamaguchi
Mar 3, 2017·Scientific Reports·Simon GuiraudKay E Davies
Jul 5, 2007·Journal of Child Neurology·Manuel Castro-GagoJesús Devesa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Related Papers

Annual Review of Cell and Developmental Biology
Se-Jin Lee
American Journal of Physiology. Cell Physiology
Robert W Jackman, Susan C Kandarian
Journal of Child Neurology
Manuel Castro-GagoJesús Devesa
© 2022 Meta ULC. All rights reserved