PMID: 12769986May 29, 2003Paper

Myotropic effect of helicokinins, tachykinin-related peptides and Manduca sexta allatotropin on the gut of Heliothis virescens (Lepidoptera: Noctuidae)

Journal of Insect Physiology
U OehR Nauen

Abstract

Different insect neuropeptides (helicokinins, tachykinin-related and allatoregulating peptides) were investigated with regard to their myostimulatory effects using whole-gut preparations isolated from fifth instar Heliothis virescens larvae. The experiments demonstrated that representatives of all three peptide families are able to induce and amplify gut contractions in this species in a dose-dependent manner. Structure-activity studies (alanine scan, D-amino acid scan and truncated analogues) with the helicokinin Hez-K1 supported the finding, that the core sequence for biological activity of kinins is the amidated C-terminal pentapeptide (FSPWG-amide). Similar investigations with insect tachykinin isolated from Leucophaea madera (Lem-TRP1) revealed that the minimum sequence evoking a physiological gut response in H. virescens is the amidated hexapeptide (GFLGVR-amide), which represents the conserved amino acid sequence for Leucophaea TRPs in general. The peptide concentration causing a half-maximal gut contraction (EC(50)) for Lem-TRP1 was about 26 nM. Although the potency of Lem-TRP1 was 9-fold lower compared with Hez-KI (EC(50): 3 nM), the maximal tension of the gut obtained with Lem-TRP1 was 1.7-fold higher compared with He...Continue Reading

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Citations

May 24, 2005·Cell and Tissue Research·Salvador Hernández-MartínezFernando G Noriega
Mar 10, 2012·Arthropod Structure & Development·Carsten M HeuerJoachim Schachtner
Sep 9, 2008·General and Comparative Endocrinology·N Audsley, R J Weaver
Apr 2, 2008·Journal of Insect Physiology·N AudsleyR J Weaver
Oct 1, 2009·Chembiochem : a European Journal of Chemical Biology·Tino ZdobinskyHeru Chen
Sep 30, 2009·Journal of Peptide Science : an Official Publication of the European Peptide Society·Jürgen ScherkenbeckHeru Chen
Apr 14, 2006·Archives of Insect Biochemistry and Physiology·Anna RachinskySonny B Ramaswamy
Oct 31, 2006·Journal of Insect Physiology·Salvador Hernández-MartínezFernando G Noriega
Mar 18, 2004·Archives of Insect Biochemistry and Physiology·Mohatmed Abdel-LatiefKlaus H Hoffmann
Jul 16, 2005·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Susan M RankinStephen S Tobe
Feb 3, 2009·Bioorganic & Medicinal Chemistry·Jürgen Scherkenbeck, Tino Zdobinsky
Aug 29, 2017·The Journal of Comparative Neurology·Xin-Cheng ZhaoUwe Homberg

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