Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology.

Trends in Molecular Medicine
Karim HniaJocelyn Laporte

Abstract

The myotubularin family of phosphoinositide phosphatases includes several members mutated in neuromuscular diseases or associated with metabolic syndrome, obesity, and cancer. Catalytically dead phosphatases regulate their active homologs by heterodimerization and potentially represent key players in the phosphatase-kinase balance. Although the enzymatic specificity for phosphoinositides indicates a role for myotubularins in endocytosis and membrane trafficking, recent findings in cellular and animal models suggest that myotubularins regulate additional processes including cell proliferation and differentiation, autophagy, cytokinesis, and cytoskeletal and cell junction dynamics. In this review, we discuss how myotubularins regulate such diverse processes, emphasizing newly identified functions in a physiological and pathological context. A better understanding of myotubularin pathophysiology will pave the way towards therapeutic strategies.

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·Z Y ZhangJ E Dixon
Aug 26, 1998·Neuromuscular Disorders : NMD·C A Sewry
Jul 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·G S TaylorJ E Dixon
Apr 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Soo-A KimJack E Dixon
Jul 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Harshal H NandurkarChristina A Mitchell
Aug 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yasuhiro Mochizuki, Philip W Majerus
Jun 10, 2004·Cell·Andres AlonsoTomas Mustelin
Nov 24, 2004·The Journal of Cell Biology·Alessandra BolinoLawrence Wrabetz
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annalisa BolisAlessandra Bolino
Jul 11, 2006·Trends in Cell Biology·Fred L Robinson, Jack E Dixon
Aug 18, 2006·The Journal of Biological Chemistry·Papiya ChoudhuryEdward Y Skolnik
Sep 30, 2006·Human Molecular Genetics·Valérie ToschJocelyn Laporte
Jan 20, 2007·Biochemical Society Symposium·Sophie CoronasBernard Payrastre
Sep 15, 2007·Human Molecular Genetics·Kristian TersarUeli Suter
Sep 15, 2007·Human Molecular Genetics·Takahiro YanagiyaKikuko Hotta
Mar 11, 2008·Trends in Cell Biology·Kenneth R Myers, James E Casanova
Mar 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fred L RobinsonJack E Dixon
Apr 24, 2008·Traffic·Anne-Sophie Nicot, Jocelyn Laporte
Jul 16, 2008·Archives of Neurology·Stéphanie BaulacRima Nabbout
Sep 9, 2008·Trends in Biochemical Sciences·Odile LecompteJocelyn Laporte
Nov 29, 2008·The Journal of Biological Chemistry·Jun ZouPhilip W Majerus
Jul 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Annalisa BolisAlessandra Bolino
Jul 11, 2009·The EMBO Journal·Isabelle VergneVojo Deretic
Oct 21, 2009·The Journal of Cell Biology·Fuminori TsurutaRicardo E Dolmetsch
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lama Al-QusairiAnna Buj-Bello
Jan 21, 2010·Physiological Reviews·Juha SaarikangasPekka Lappalainen

❮ Previous
Next ❯

Citations

Aug 1, 2013·Human Molecular Genetics·Rafael PulidoWiljan J A J Hendriks
Sep 6, 2013·Skeletal Muscle·Aaron ReiflerJames J Dowling
May 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Salam Herojeet SinghUpendra Nongthomba
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Masashi MaekawaHiroyuki Arai
Mar 5, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ivana ProkicJocelyn Laporte
Jan 22, 2013·Annual Review of Immunology·Klaus Okkenhaug
Oct 20, 2014·Nature Chemical Biology·Baptiste RonanBenoit Pasquier
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paola NixMichael Bastiani
Jan 2, 2013·The Journal of Cell Biology·Evgenia LeikinaLeonid V Chernomordik
Sep 24, 2015·Biochimie·Julien ViaudBernard Payrastre
Nov 18, 2015·The FEBS Journal·Andrés Alonso, Rafael Pulido
Apr 30, 2015·Glia·Kelly R MonkCarla Taveggia
Jun 21, 2013·Journal of the Peripheral Nervous System : JPNS·Marco LuigettiMario Sabatelli
Nov 19, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Assia ShishevaOgnian Ikonomov
Jan 29, 2013·BMB Reports·Young Jun KimYoung Yil Bahk
Aug 2, 2015·Cell·UNKNOWN Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium
Apr 22, 2014·Seminars in Cell & Developmental Biology·Françoise Hullin-MatsudaToshihide Kobayashi
Dec 3, 2014·Biochimica Et Biophysica Acta·Clothilde Cauvin, Arnaud Echard
Jun 27, 2014·The Biochemical Journal·Peter G Billcliff, Martin Lowe
Sep 30, 2014·Biochimica Et Biophysica Acta·FoSheng Hsu, Yuxin Mao
Mar 12, 2015·Acta Crystallographica. Section F, Structural Biology Communications·Seoung Min BongByung Il Lee
Dec 17, 2014·Biochimica Et Biophysica Acta·Leopoldo StaianoMaria Antonietta De Matteis
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Apr 30, 2013·American Journal of Human Genetics·Philippe M CampeauBrendan H Lee
Aug 7, 2013·Archives of Biochemistry and Biophysics·Assia Shisheva
May 8, 2016·Biochemical and Biophysical Research Communications·Rana MansourBernard Payrastre
Jul 19, 2016·Seminars in Cell & Developmental Biology·Susan TrevesFrancesco Zorzato
Aug 23, 2016·The Journal of Clinical Investigation·Nesrin SabhaJames J Dowling
Dec 16, 2016·Neuropathology and Applied Neurobiology·C A Sewry, C Wallgren-Pettersson
Mar 16, 2017·International Journal of Molecular Sciences·Johan-Owen De CraeneSylvie Friant
Feb 7, 2018·Journal of Neuropathology and Experimental Neurology·Nathalie DanièleAna Buj-Bello
Apr 15, 2017·Biochemical Society Transactions·Arya Dahal, Shantá D Hinton
Jan 10, 2018·Frontiers in Immunology·Didier Soulat, Christian Bogdan
Jul 3, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hoa Q PhamYoh Takuwa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.