Myricanol mitigates lipid accumulation in 3T3-L1 adipocytes and high fat diet-fed zebrafish via activating AMP-activated protein kinase

Food Chemistry
Shengnan ShenLigen Lin

Abstract

Myricanol is a diarylheptanoid isolated from Chinese bayberry. Through virtual docking strategy, myricanol was discovered as an AMP-activated protein kinase (AMPK) activator among a series of structural analogs, with high affinity for the γ subunit of AMPK. Myricanol was also evaluated for regulatory effects on lipid accumulation and insulin sensitivity in 3T3-L1 adipocytes and adiposity in high-fat diet-fed zebrafish. Myricanol suppressed lipid accumulation in 3T3-L1 cells in the initial stage (days 0-2) by suppressing adipogenesis and in the terminal stage (days 4-7) by inducing lipolysis and lipid combustion through activating AMPK. Moreover, myricanol enhanced insulin-stimulated glucose uptake by activating the insulin signaling pathway. In high-fat diet-fed zebrafish, myricanol inhibited lipid accumulation by suppressing adipogenic factors including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα). In summary, the results indicate that myricanol could be a potential therapeutic agent against obesity by activating the AMPK signaling pathway.

Citations

Jan 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhu-Jun FangLi-She Gan
Oct 2, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruilin ZhangXuewu Zhang
Jan 16, 2020·International Journal of Molecular Sciences·Tian ZhangLigen Lin
Dec 5, 2020·Oxidative Medicine and Cellular Longevity·Xueying LiuChuangpeng Shen
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gonçalo P RosaMaria Carmo Barreto
Jun 2, 2021·Critical Reviews in Food Science and Nutrition·Fang-Jun LinRen-You Gan
May 19, 2021·Progress in Biophysics and Molecular Biology·Harshita Singh, Navneeta Bharadvaja

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