Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway

International Journal of Oncology
Haizhi HuangYi Charlie Chen

Abstract

Cisplatin is a commonly used drug for cancer treatment by crosslinking DNA, leading to apoptosis of cancer cells, resistance to cisplatin treatment often occurs, leading to relapse. Therefore, there is a need for the development of more effective treatment strategies that can overcome chemoresistance. Myricetin is a flavonoid from fruits and vegetables, showing anticancer activity in various cancer cells. In this study, we found myricetin exhibited greater cytotoxicity than cisplatin in two cisplatin-resistant ovarian cancer cell lines, OVCAR-3 and A2780/CP70, and it was less cytotoxic to the normal ovarian cell line IOSE-364. Myricetin selectively induced apoptosis in both cisplatin-resistant cancer cell lines, but did not induce apoptosis in the normal ovarian cell line. It induced both Bcl-2 family-dependent intrinsic and DR5 dependent extrinsic apoptosis in OVCAR-3 cells. P53, a multifunctional tumor suppressor, regulated apoptosis in OVCAR-3 cells through a Bcl-2 family protein-dependent pathway. Myricetin did not induce cell cycle arrest in either ovarian cancer cell line. Because of its potency and selectivity against cisplatin-resistant cancer cells, myricetin could potentially be used to overcome cancer chemoresistance...Continue Reading

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Citations

Apr 26, 2016·International Journal of Molecular Sciences·Hong-Hao ZhouXiao-Ping Chen
Jul 3, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhiqing ZhouYanli He
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Aug 3, 2020·BMC Complementary Medicine and Therapies·Yasaman TaheriJavad Sharifi-Rad
Feb 20, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lusia Barek MosesZaleha Abdul Aziz

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Methods Mentioned

BETA
flow cytometry
FCS
Protein Assay
transfection

Software Mentioned

SPSS
FCS
Excel

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