Myrosinase-treated glucoerucin is a potent inducer of the Nrf2 target gene heme oxygenase 1--studies in cultured HT-29 cells and mice.

The Journal of Nutritional Biochemistry
Anika E WagnerGerald Rimbach

Abstract

In this study, the effect of myrosinase-treated glucoerucin (GER+MYR), which releases the isothiocyanate (ITC) erucin, on heme oxygenase 1 (HO-1) gene expression and Nrf2 signaling was investigated in vitro in cultured cells and in vivo in mice. Treatment of HT-29 cells with GER+MYR resulted in a significant increase in the mRNA and protein levels of nuclear Nrf2 and HO-1. GER+MYR was more potent at enhancing the nuclear Nrf2 levels than were the following myrosinase-treated glucosinolates: sinigrin, glucoraphanin and gluconasturtiin, which are the precursors of allyl-ITC, R-sulforaphane and 2-phenylethyl ITC, respectively. GER+MYR also significantly induced HO-1 gene expression in the mouse intestinal mucosae and liver but not in the brain. Mechanistic studies suggest that GER+MYR induces Nrf2 via ERK1/2-, p38- and JNK-dependent signal transduction pathways. The GER+MYR-mediated increase in HO-1 expression is primarily attributable to p38 signaling.

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Citations

Sep 2, 2017·International Journal of Molecular Sciences·Christine Sturm, Anika E Wagner
May 9, 2018·Nutrients·Mohammed Sani JaafaruAhmad Faizal Abdull Razis
Apr 4, 2019·Critical Reviews in Biotechnology·Rohini Bhat, Dhiraj Vyas
Mar 19, 2019·Molecular Nutrition & Food Research·Yue-Bang YinYu-Long Yin
Mar 8, 2017·Experimental Cell Research·Xin WangFang Wang

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