Myxoid adrenocortical adenoma with a pseudoglandular pattern

Virchows Archiv : an International Journal of Pathology
Enrico R BollitoGregor Mikuz

Abstract

Myxoid changes rarely occur in adrenocortical adenomas and carcinomas. Only eight benign tumours with such features have been described thus far, five of which also had a prominent pseudoglandular component. We report an additional pseudoglandular myxoid adenoma of the adrenal gland detected in a 58-year-old male patient who developed mild hypertension. At surgery, a 4-cm mass was resected and found to contain cords and tubules of polygonal cells in a myxoid background. Limited areas of classical adrenocortical adenoma were detected in less than 20% of the tumour area. Lack of atypias and absence of mucin markers, together with an immunophenotype consistent with adrenal tumours (focal cytokeratin, vimentin, synaptophysin and alpha-inhibin immunoreactivities), led to a diagnosis of primary adrenocortical adenoma with an extensive pseudoglandular myxoid pattern. However, the differential diagnosis from metastatic well-differentiated adenocarcinomas, chordomas and retroperitoneal myxoid mesenchymal tumours (e.g. liposarcoma) may be difficult in the absence of a complete clinical history and a reliable immunoprofile. We strongly recommend staining of any myxoid or glandular tumour of the adrenal gland for alpha-inhibin and synaptop...Continue Reading

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Citations

Jun 11, 2010·The American Journal of Surgical Pathology·Mauro PapottiJuan Rosai
Nov 17, 2011·Virchows Archiv : an International Journal of Pathology·Ronald R de Krijger, Thomas G Papathomas
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Gaurav ChatterjeeSugato Banerjee
Jan 20, 2009·Pathology·Kyu Yun JangYoung Bum Jeong
Dec 15, 2017·Histopathology·Lori A Erickson
Mar 20, 2014·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Tae Un KimWon Young Park

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