Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study

Histopathology
John R LozadaFelipe C Geyer

Abstract

Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Conventional fibroadenomas (FAs) are underpinned by recurrent MED12 mutations in the stromal components of the lesions. The aim of this study was to investigate the genomic landscape of MFAs and compare it with that of conventional FAs. Eleven MFAs from patients without clinical and/or genetic evidence of Carney complex were retrieved. DNA samples of tumour and matching normal tissue were subjected to massively parallel sequencing using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay, an assay targeting 410 cancer genes. Genetic alterations detected by MSK-IMPACT were tested in samples in which the stromal and epithelial components were separately laser capture-microdissected. Sequencing revealed no germline PRKAR1A mutations and non-synonymous mutations in six MFAs. Interestingly, in three of the MFAs in which the stromal and epithelial components were separately microdissected, the mutations were found to be restricted to the epithelial r...Continue Reading

References

Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R MillikanL J Melton
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·C A StratakisJ A Carney
Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
Sep 8, 2004·Cancer Genetics and Cytogenetics·Luciane R CavalliBassem R Haddad
Sep 16, 2004·American Journal of Medical Genetics. Part a·Ekaterini T TsilouConstantine A Stratakis
Jun 8, 2006·Orphanet Journal of Rare Diseases·Jérôme Bertherat
Aug 26, 2006·Pathology International·Mi-Jung KimKyung-Ja Cho
Aug 3, 2010·Nature Methods·Jana Marie SchwarzDominik Seelow
May 15, 2012·Bioinformatics·Christopher T SaundersR Keira Cheetham
Aug 29, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Jorge Rojo ÁlvaroPatricia Munárriz Alcuaz
Oct 12, 2012·PloS One·Yongwook ChoiAgnes P Chan
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Mar 13, 2014·The American Journal of Surgical Pathology·Joseph J MaleszewskiBenjamin R Kipp
Apr 10, 2015·Histopathology·Salvatore PiscuoglioJorge S Reis-Filho
Jul 2, 2015·European Journal of Endocrinology·Ricardo CorreaConstantine A Stratakis
Sep 12, 2015·The Korean Journal of Internal Medicine·Yi Sun JangHye Soo Kim
Oct 6, 2015·Nature Genetics·Jing TanBin Tean Teh
Nov 26, 2015·The Journal of Pathology·Salvatore PiscuoglioBritta Weigelt
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
Jun 4, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Su-Yang LiuGregor Krings

❮ Previous
Next ❯

Citations

Dec 19, 2017·Journal of Clinical Pathology·Benjamin Nathanael LokePuay Hoon Tan
May 29, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Puay Hoon Tan
Feb 23, 2019·Histopathology·John R LozadaTravis J Hollmann
Nov 14, 2020·Clinical Imaging·Isil Basara Akin, Pinar Balci
Dec 31, 2020·Journal of Clinical Pathology·Edaise M da SilvaHong Zhang
Jul 30, 2021·Virchows Archiv : an International Journal of Pathology·Emad A RakhaCecily Quinn
Sep 11, 2021·Virchows Archiv : an International Journal of Pathology·Melinda F LerwillPuay Hoon Tan
Oct 12, 2021·Experimental and Therapeutic Medicine·Florica SandruDiana Loreta Paun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.