Myxoid liposarcoma with heterologous components: dedifferentiation or metaplasia? A FISH-documented and CGH-documented case report

Applied Immunohistochemistry & Molecular Morphology : AIMM
Noëlle WeingertnerJean-Pierre Ghnassia

Abstract

Heterologous differentiation in myxoid liposarcoma is a rare phenomenon. Few cases have been reported thus far, often without molecular assays, and the concept of "dedifferentiated" myxoid liposarcoma remains controversial. We describe a primary myxoid liposarcoma with chondroid and osseous components affecting the right thigh of a 27-year-old woman. We wondered whether these areas represented dedifferentiated components or simply metaplasia, and performed fluorescent in situ hybridization and array comparative genomic hybridization assays in the myxoid liposarcoma component and chondroid component. Fluorescent in situ hybridization analysis demonstrated a DDIT3 gene rearrangement in both components; array comparative genomic hybridization analysis did not detect any gain or loss of DNA regions in both components. Our results, demonstrating that both components have the same molecular alterations, suggest that heterologous components seen in some myxoid liposarcomas reflect a metaplastic phenomenon and not a real dedifferentiation phenomenon, challenging the concept of "dedifferentiated" myxoid liposarcoma.

References

Dec 1, 1996·Cancer Genetics and Cytogenetics·T DijkhuizenE van den Berg
Sep 1, 1996·Journal of Clinical Pathology·J H ShanksB P Eyden
Sep 30, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ronald S A de VreezeFrits van Coevorden
Jan 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aimee M CragoSamuel Singer

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Citations

Aug 21, 2020·The American Journal of Surgical Pathology·Jason V ScapaGregory W Charville

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Methods Mentioned

BETA
biopsy
Feature Extraction

Software Mentioned

Feature Extraction
Agilent Genomic Workbench Lite
SpectrumOrange

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