Abstract
While focal myxoid areas are occasionally observed in solitary fibrous tumors, neoplasms of this type exhibiting extensive myxoid change are considered exceedingly uncommon. Due to their rarity, the biologic behavior of myxoid solitary fibrous tumor has not been determined. Three cases of myxoid solitary fibrous tumor are described in order to better characterize the clinical and pathologic features of this uncommon variant of solitary fibrous tumor. The tumors occurred in one man and two women, with ages of 37, 47, and 58 years, respectively. Sites of involvement included the retroperitoneum, pelvis, and soft tissue of the neck. Histologically, all cases were characterized predominantly by the presence of myxoid stroma comprising 70% to 100% of the tumor. The tumor cells were predominantly spindled in all cases, and arranged randomly, in loose fascicles, or in anastomosing strands imparting a microcystic/reticular appearance. The lesional cells had a bland cytologic appearance and low mitotic count. All tumors lacked necrosis and areas of increased cellularity. By immunohistochemistry, all cases were positive for CD34, CD99, and bcl-2, and negative for keratin, epithelial membrane antigen, desmin, actin, smooth muscle actin, a...Continue Reading
References
Aug 1, 1989·The American Journal of Surgical Pathology·D M EnglandM J McCarthy
Nov 1, 1995·The American Journal of Surgical Pathology·S SusterC A Moran
Jun 1, 1993·The American Journal of Surgical Pathology·H L Evans
Apr 1, 1996·The American Journal of Surgical Pathology·T MentzelC D Fletcher
Apr 15, 1996·Cancer·S E KilpatrickA G Nascimento
Feb 3, 1998·Histopathology·J K Chan
Dec 16, 1998·The American Journal of Surgical Pathology·A V Vallat-DecouvelaereC D Fletcher
Nov 17, 1999·Histopathology·J F Graadt van RoggenC D Fletcher
Feb 10, 2000·Human Pathology·T HasegawaS Hirohashi
Jul 15, 2000·The American Journal of Surgical Pathology·B P Rubin, C D Fletcher
Dec 8, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y MorimitsuH Hashimoto
Nov 28, 2002·The British Journal of Dermatology·S-E ChangJ S Silverman
Feb 1, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T YapI Taylor
Jun 1, 2005·Virchows Archiv : an International Journal of Pathology·Nestor M PakasaMichel Péoc'h
Dec 20, 2005·Histopathology·C Gengler, L Guillou
Feb 18, 2006·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Nai-Chen ChengHsiung-Fei Chien
Sep 19, 2006·Histopathology·M KösemO Unal
Sep 21, 2006·Pathology International·Yu-Ching WeiHsuan-Ying Huang
Aug 28, 2007·The American Journal of Surgical Pathology·Julie D R Reimann, Christopher D M Fletcher
Aug 28, 2007·The American Journal of Surgical Pathology·Louis GuillouJean-Michel Coindre
Sep 25, 2007·The American Journal of Dermatopathology·Thomas MentzelMichal Michal
Jun 6, 2008·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Sang Soo ShinHeoung Keun Kang
Citations
Feb 22, 2012·Clinical Obstetrics and Gynecology·Christopher P CrumWa Xian
Feb 26, 2010·The American Journal of Surgical Pathology·Rajal B ShahMing Zhou
Mar 12, 2010·The American Journal of Surgical Pathology·Bo HanRajal B Shah
Apr 28, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Marco GessiTorsten Pietsch
Mar 5, 2016·Surgical Case Reports·Takehiro MakiKazuyoshi Nihei
Nov 19, 2011·Clinical and Experimental Dermatology·H-J LeeM R Roh
Jan 1, 2012·Gynecologic Oncology Case Reports·Joao CasanovaGabriel Madureira
Dec 4, 2014·Pathology, Research and Practice·Louis Tsun Cheung Chow
Aug 21, 2014·The American Journal of Dermatopathology·Jin Yong LeeKwang Ho Kim
Sep 7, 2017·The American Journal of Surgical Pathology·Steven C SmithJonathan B McHugh
Jul 20, 2011·Applied Immunohistochemistry & Molecular Morphology : AIMM·Abbas AgaimyWolfgang Holter
Dec 5, 2019·Head and Neck Pathology·Bingcheng WuFredrik Petersson
Dec 19, 2012·International Journal of Surgical Pathology·Kossivi Dantey, Kumarasen Cooper
Mar 31, 2018·CytoJournal·Hiromi TakahashiKuniaki Nakanishi
Jan 5, 2021·Pathologica·Gaetano MagroSergio Castorina