Myxoid solitary fibrous tumor: a clinicopathologic study of three cases.

Virchows Archiv : an International Journal of Pathology
Sean K LauPeiguo G Chu

Abstract

While focal myxoid areas are occasionally observed in solitary fibrous tumors, neoplasms of this type exhibiting extensive myxoid change are considered exceedingly uncommon. Due to their rarity, the biologic behavior of myxoid solitary fibrous tumor has not been determined. Three cases of myxoid solitary fibrous tumor are described in order to better characterize the clinical and pathologic features of this uncommon variant of solitary fibrous tumor. The tumors occurred in one man and two women, with ages of 37, 47, and 58 years, respectively. Sites of involvement included the retroperitoneum, pelvis, and soft tissue of the neck. Histologically, all cases were characterized predominantly by the presence of myxoid stroma comprising 70% to 100% of the tumor. The tumor cells were predominantly spindled in all cases, and arranged randomly, in loose fascicles, or in anastomosing strands imparting a microcystic/reticular appearance. The lesional cells had a bland cytologic appearance and low mitotic count. All tumors lacked necrosis and areas of increased cellularity. By immunohistochemistry, all cases were positive for CD34, CD99, and bcl-2, and negative for keratin, epithelial membrane antigen, desmin, actin, smooth muscle actin, a...Continue Reading

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Citations

Feb 22, 2012·Clinical Obstetrics and Gynecology·Christopher P CrumWa Xian
Apr 28, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Marco GessiTorsten Pietsch
Nov 19, 2011·Clinical and Experimental Dermatology·H-J LeeM R Roh
Jan 1, 2012·Gynecologic Oncology Case Reports·Joao CasanovaGabriel Madureira
Aug 21, 2014·The American Journal of Dermatopathology·Jin Yong LeeKwang Ho Kim
Sep 7, 2017·The American Journal of Surgical Pathology·Steven C SmithJonathan B McHugh
Dec 19, 2012·International Journal of Surgical Pathology·Kossivi Dantey, Kumarasen Cooper
Mar 31, 2018·CytoJournal·Hiromi TakahashiKuniaki Nakanishi

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