PMID: 1413498Nov 1, 1992

Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence

K GrahamGrant McFadden


Myxoma virus (MYX) induces extensive immunosuppression in infected rabbits and is associated with high levels of mortality. The virus encodes multiple gene products designed to circumvent the cellular immune response to the viral infection. Deletion analysis has shown that the M11L open reading frame (ORF) is an important virulence factor which downregulates leukocyte infiltration of MYX-induced tumors. To investigate the role of the M11L protein in viral pathogenesis, we sequenced the MYX M11L ORF and showed that the sequence has motifs consistent with a 166-aa class III membrane-spanning molecule possessing a single transmembrane helix near the C-terminus and a 142-aa N-terminal extracellular domain that has six cysteine residues plus two consensus N-glycosylation sites. Transcription analysis indicates that M11L is expressed as an early gene, and surface immunofluorescence studies with anti-M11L antibodies reveal that M11L protein is transported to the infected cell surface. Immunoprecipitation analysis of an attenuated viral recombinant, vMYX-GF-delta M11L, indicates that an M11L variant protein with an altered C-terminus is synthesized at about 45% of wild type levels; however, it is not detectable on the cell surface, sug...Continue Reading


Dec 2, 1991·International Journal of Cancer. Journal International Du Cancer·M OkabayashiJ W Kreider
Apr 15, 1991·Biochemical and Biophysical Research Communications·C A SmithR G Goodwin
Jan 1, 1990·Annual Review of Biochemistry·B Moss
Jul 1, 1990·Computer Applications in the Biosciences : CABIOS·D L BrutlagJ Relph
May 1, 1989·Virology·R J Russell, S J Robbins
Jun 9, 1988·Biochimica Et Biophysica Acta·G von Heijne
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L Yuen, B Moss
May 1, 1969·Virology·Y UedaI Tagaya
Oct 25, 1980·Journal of Molecular Biology·F SangerB A Roe
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle
Sep 1, 1962·Virology·W K JOKLIK


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Related Concepts

M11L protein, Myxoma virus
DNA, Viral
Myxoma virus
Precipitin Tests
Viral Proteins
Immunoblotting, Reverse
Restriction Mapping
Unassigned Reading Frames
Homologous Sequences, Amino Acid

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