N -Acetylcysteine inhalation improves pulmonary function in patients received liver transplantation

Bioscience Reports
Xiaoyun LiWeifeng Yao

Abstract

Postoperative pulmonary complications (PPCs) following orthotopic liver transplantation (OLT) are associated with high morbidity and mortality rates. The effect of N-acetylcysteine (NAC) inhalation on the incidence of PPCs and the outcomes of patients undergoing OLT is unknown. This prospective randomized controlled clinical trial was conducted to investigate the effect of NAC inhalation during OLT on PPCs. Sixty patients were randomly assigned to the NAC group (n = 30) or the control group (n = 30) to receive inhaled NAC or sterilized water, respectively, for 30 min before surgery and 3 h after reperfusion. The incidence of early PPCs and outcomes including survival rate were assessed. Biomarkers including tumor necrosis factor (TNF)-α, interleukin (IL)-8, Clara cell secretory protein (CC16), intercellular adhesion molecule (ICAM)-1, and superoxide dismutase (SOD) were measured in exhaled breath condensate (EBC) at T1 (before surgery) and T2 (at the end of operation) as well as in serum at T1, T2, T3 (12 h after operation), and T4 (24 h after operation). A total of 42 patients (20 in the NAC group and 22 in the control group) were enrolled in the final analysis. Atomization inhaled NAC significantly reduced the incidence of PP...Continue Reading

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Citations

Jan 5, 2020·Digestive Diseases and Sciences·Zheng ZhangZiqing Hei
Oct 24, 2020·Life Sciences·Gerwyn MorrisMichael Berk
Aug 10, 2021·Frontiers in Physiology·Mylarappa NingappaRakesh Sindhi

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Methods Mentioned

BETA
X-ray
bronchoalveolar
lavage
scanning electron microscopy

Software Mentioned

SPSS

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