N -Methyl-β-carbolinium Salts and an N -Methylated 8-Oxoisoguanine as Acetylcholinesterase Inhibitors from a Solitary Ascidian, Cnemidocarpa irene

ACS Omega
Yohei TadokoroRyuichi Sakai

Abstract

New brominated β-carbolines irenecarbolines A (1) and B (4) along with known β-carbolines 2 and 3 and a new 8-oxoisoguanine derivative, 5, were isolated from a solitary ascidian, Cnemidocarpa irene. The structures of these compounds were determined on the basis of their spectral data. All, except for 3, inhibited the action of acetylcholinesterase (AchE). The activities of 1 and 5 were comparable to those of galantamine, a clinically used AchE inhibitor. Compounds 1 and 2 were found to be present in high concentrations in blood, and fluorescence was observed in certain types of cells found in the blood of the tunicate.

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Citations

Mar 30, 2019·Natural Product Reports·Lindon W K MoodieJohan Svenson
Jul 7, 2020·Organic & Biomolecular Chemistry·M Paula DenofrioFranco M Cabrerizo
May 15, 2018·Marine Drugs·Dianne J Watters
Dec 29, 2020·European Journal of Pharmacology·Yusuf Oloruntoyin AyipoThenmoly Damodaran
Feb 3, 2021·Journal of Medicinal Chemistry·Aurélien BeatoRomain Haudecoeur
Oct 9, 2020·Journal of Natural Products·Kei MiyakoRyuichi Sakai

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Methods Mentioned

BETA
NMR
gel-filtration

Software Mentioned

GraphPad Prism

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