N 1-methyladenosine (m1A) RNA modification: the key to ribosome control?

Journal of Biochemistry
Hiroki Shima, Kazuhiko Igarashi

Abstract

RNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N1-methyladenosine (m1A) is found mainly in tRNA and rRNA of many living organisms, and is known to be deeply implicated in the topology or function of the two classes of RNA. In this commentary article, we would like to deal with the functional significance of m1A in RNA, and also to describe one methyltransferase installing m1A in a large subunit rRNA, whose orthologue in C. elegans was discovered recently and was reported in this journal.

References

Oct 1, 1968·Biochemistry·J B Macon, R Wolfenden
Jan 1, 1996·Progress in Nucleic Acid Research and Molecular Biology·P F Agris
Jan 1, 1961·Biochimica Et Biophysica Acta·D B DUNN
Jul 7, 2005·Genes & Development·Benjamin HamiltonSiu Sylvia Lee
Dec 1, 2005·The Journal of Biological Chemistry·Naoki ShigiKimitsuna Watanabe
Apr 7, 2007·PLoS Genetics·Sean P Curran, Gary Ruvkun
Aug 4, 2007·Methods in Enzymology·Yuri MotorinChristiane Branlant
Nov 13, 2010·Nucleic Acids Research·William A CantaraPaul F Agris
Aug 9, 2011·Wiley Interdisciplinary Reviews. RNA·Yuri Motorin, Mark Helm
Jun 8, 2012·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jun-ichi Wachino, Yoshichika Arakawa
Jul 27, 2012·Nucleic Acids Research·Zhi-Wei DongLiang-Hu Qu
Nov 28, 2012·Nucleic Acids Research·Christian PeiferKarl-Dieter Entian
Apr 22, 2014·Cell Reports·Shohei OieAkiko Murayama
May 17, 2014·Nucleic Acids Research·Takeo Suzuki, Tsutomu Suzuki
Jun 7, 2014·Frontiers in Genetics·Hiroyuki Hori
Jan 23, 2015·RNA Biology·Magdalena A MachnickaJanusz M Bujnicki
Sep 15, 2015·Nucleic Acids Research·Ralf HauenschildMark Helm
Sep 28, 2015·Trends in Biochemical Sciences·Sunny Sharma, Denis L J Lafontaine
Jun 3, 2016·Wiley Interdisciplinary Reviews. RNA·Patrick A Limbach, Mellie June Paulines
Jan 20, 2017·Nature·Emily M HarcourtEric T Kool
Feb 22, 2017·Nature Reviews. Genetics·Mark Helm, Yuri Motorin
Feb 24, 2017·Biomolecules·Stephanie OerumCarine Tisné
Apr 5, 2017·Biomolecules·Christian LorenzMario Mörl
Nov 7, 2017·Nucleic Acids Research·Pietro BoccalettoJanusz M Bujnicki
Nov 17, 2017·Nature·S Kundhavai NatchiarBruno P Klaholz
Dec 16, 2017·Journal of Biochemistry·Shohei MurakamiHozumi Motohashi
Feb 1, 2018·Journal of Biochemistry·Wataru YokoyamaAkiyoshi Fukamizu
Feb 15, 2018·Nature Chemical Biology·Petr V SergievOlga A Dontsova
Sep 7, 2018·Open Biology·Anna Ovcharenko, Andrea Rentmeister
Sep 17, 2018·Journal of Biochemistry·Koichiro KakoAkiyoshi Fukamizu
Apr 28, 2019·The Biochemical Journal·R Jordan OntiverosKathy Fange Liu
May 10, 2019·F1000Research·Nigel P MonganNathan Archer
Nov 14, 2019·Nature Communications·Anya V GrozhikSamie R Jaffrey

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Citations

May 7, 2021·Cardiovascular Research·Rajesh KumariSuresh Kumar Verma
Jul 15, 2021·Chemical Society Reviews·David BarteeJordan L Meier
Jul 31, 2021·Journal of Medical Virology·Pei-Lun YuQi-Gui Yan

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