N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide: an orally bioavailable melatonin receptor agonist

Bioorganic & Medicinal Chemistry Letters
Li-Qiang SunCen Xu

Abstract

N-[2-[2-(4-Phenylbutyl)benzofuran-4-yl]cyclopropylmethyl]acetamide 3a was synthesized as an orally bioavailable agonist at MT1 and MT2 melatonin receptors with significantly low vasoconstrictive activity.

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Citations

Mar 2, 2016·Advanced Drug Delivery Reviews·Christel A S BergströmChristopher J H Porter
May 11, 2011·CNS Neuroscience & Therapeutics·Gilberto SpadoniMarco Mor
Feb 24, 2015·European Journal of Medicinal Chemistry·Ashish Radadiya, Anamik Shah
May 28, 2015·European Journal of Medicinal Chemistry·Reshma J NevagiSatish N Dighe
Feb 17, 2005·Bioorganic & Medicinal Chemistry Letters·Li-Qiang SunCen Xu
Jul 15, 2009·Archiv der Pharmazie·Rondla RohiniVadde Ravinder
Jun 14, 2005·Archiv der Pharmazie·Darius P Zlotos
Jun 11, 2010·Expert Opinion on Therapeutic Patents·Marco MorGiorgio Tarzia
Jun 13, 2020·Journal of Pineal Research·Jean A BoutinDarius P Zlotos
Aug 12, 2017·Nature Communications·Jiang-Ling ShiZhang-Jie Shi

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