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N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity

Neurochemistry International

May 11, 2019

Elisa LanducciLaura Raimondi

Abstract

Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kaini...read more

Mentioned in this Paper

M Protein, multiple myeloma
AKT1
Western Blotting
Tissue Damage
Neurons
Propidium Iodide
Cessation of Life
TAAR1 protein, human
Neuroprotection
N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamide
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N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamide (EPPTB) prevents 3-iodothyronamine (T1AM)-induced neuroprotection against kainic acid toxicity

Neurochemistry International

May 11, 2019

Elisa LanducciLaura Raimondi

PMID: 31075293

DOI: 10.1016/j.neuint.2019.05.004

Abstract

Thyroid hormone and thyroid hormone metabolites, including 3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1), activate AKT signaling in hippocampal neurons affording protection from excitotoxic damage. We aim to explore whether the mechanism of T1AM neuroprotection against kaini...read more

Mentioned in this Paper

M Protein, multiple myeloma
AKT1
Western Blotting
Tissue Damage
Neurons
Propidium Iodide
Cessation of Life
TAAR1 protein, human
Neuroprotection
N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-trifluoromethylbenzamide

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