N-3 polyunsaturated fatty acid supplementation does not reduce vulnerability to atrial fibrillation in remodeling atria

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Andrew RamadeenPaul Dorian

Abstract

Prophylactic supplementation with omega-3 polyunsaturated fatty acids (PUFAs) reduce vulnerability to atrial fibrillation (AF). The effect of PUFAs given after cardiac injury has occurred is unknown. To investigate using a model of pacing-induced cardiac injury, the time course of development of injury and whether it was altered by postinjury PUFAs. Sixty-five dogs were randomized to undergo simultaneous atrial and ventricular pacing (SAVP, 220 beats/min) for 0, 2, 7, or 14 days. Twenty-two dogs received PUFAs (850 mg/d) either prophylactically or after some pacing had occurred (postinjury). Electrophysiologic and echocardiographic measurements were taken at baseline and sacrifice. Atrial tissue samples were collected at sacrifice for histologic and molecular analyses. With no PUFAs, the inducibility of AF increased with pacing duration (P < .001). Postinjury PUFAs (started after 7 days of pacing) did not reduce the inducibility of AF after 14 days of pacing (9.3% ± 8.8% no PUFAs vs 9.7% ± 9.9% postinjury PUFAs; P = .91). Atrial myocyte size and fibrosis increased with pacing duration (P < .05). Postinjury PUFAs did not significantly attenuate the cell size increase after 14 days of pacing (no PUFAs 38% ± 30% vs postinjury PUFA...Continue Reading

References

Jul 21, 2004·Circulation·Dariush MozaffarianDavid S Siscovick
Sep 29, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Karin H HumphriesUNKNOWN Canadian Registry of Atrial Fibrillation investigators
Apr 26, 2006·Circulation·Brian DeBoschAnthony J Muslin
Jan 23, 2009·The Journal of Nutrition·Sarah M M MaddenBruce J Holub
Oct 12, 2010·The New England Journal of Medicine·Daan KromhoutUNKNOWN Alpha Omega Trial Group
Nov 10, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Leopoldo BianconiMassimo Santini
Dec 3, 2010·Journal of Cardiovascular Translational Research·Eric S RichardsonYong-Fu Xiao
Dec 15, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dennis H LauPrashanthan Sanders

❮ Previous
Next ❯

Citations

Feb 28, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Clemens von Schacky
Sep 7, 2012·Cardiology Research and Practice·Andrew Ramadeen, Paul Dorian
Sep 25, 2015·International Journal of Molecular Sciences·Georgios A ChristouJohn A Goudevenos
Mar 13, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·David R Van Wagoner
Dec 2, 2015·Biochimica Et Biophysica Acta·Sören BrandenburgStephan E Lehnart
Sep 20, 2016·The Journal of Clinical Investigation·Sören BrandenburgStephan E Lehnart
Aug 28, 2012·Circulation. Arrhythmia and Electrophysiology·Andrew RamadeenPaul Dorian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.