N-3 Polyunsaturated Fatty Acids and Inflammation in Obesity: Local Effect and Systemic Benefit

BioMed Research International
Yue Wang, Feiruo Huang

Abstract

Overwhelming consensus emerges among countless evidences that obesity is characterized by a chronic low-grade inflammation in the adipose tissue (AT), which subsequently develops into a systemic inflammatory state contributing to obesity-associated diseases. N-3 Polyunsaturated fatty acids (n-3 PUFA), known as important modulators participating in inflammatory process, turn out to be an effective mitigating strategy dealing with local and systemic inflammation observed in obesity. Some of the effects of n-3 PUFA are brought about by regulation of gene expression through interacting with nuclear receptors and transcription factors; other effects are elicited by modulation of the amount and type of mediator derived from PUFAs. The metabolic effects of n-3 PUFA mainly result from their interactions with several organ systems, not limited to AT. Notably, the attenuation of inflammation in hard-hit AT, in turn, contributes to reducing circulating concentrations of proinflammatory cytokines and detrimental metabolic derivatives, which is beneficial for the function of other involved organs. The present review highlights a bridging mechanism between n-3 PUFA-mediated inflammation relief in AT and systemic benefits.

References

Feb 1, 1992·The American Journal of Clinical Nutrition·L G ClelandR A Gibson
Jun 1, 1987·The Journal of Nutrition·A Haug, A T Høstmark
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Nov 7, 1996·Nature·P R DevchandW Wahli
Aug 1, 1997·Canadian Journal of Physiology and Pharmacology·G R Herzberg, C Skinner
May 5, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·G WinklerK Cseh
Aug 24, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T ObataK Yamashita
Jan 5, 2000·The American Journal of Clinical Nutrition·M J JamesL G Cleland
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Todd E NovakN Joseph Espat
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Nov 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A P Simopoulos
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Feb 14, 2004·Journal of the American College of Nutrition·Yan ZhaoLinda H Chen
May 12, 2004·Nature Reviews. Drug Discovery·Derek W GilroyAdriano G Rossi
Aug 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C CouetF Lamisse
Dec 28, 2004·Nature Medicine·Akira HirasawaGozoh Tsujimoto
Feb 3, 2005·Nature Medicine·Melek C ArkanMichael Karin
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea S RossiSalwa W Rizkalla

❮ Previous
Next ❯

Citations

Mar 24, 2016·Biochemical Pharmacology·Elisa Alvarez-Curto, Graeme Milligan
Apr 30, 2016·Nutrition & Metabolism·Ping ZhangFeiruo Huang
Feb 18, 2017·International Journal of Environmental Research and Public Health·Binwu ShengLu Shi
May 30, 2019·Future Medicinal Chemistry·Ana C AnauateMarília A C Smith
Feb 26, 2019·Drug Delivery·Tejinder SinghJungkyun Im
Aug 17, 2020·Nutrients·Ashley N HutchinsonRobert Jan Brummer
Sep 16, 2017·BioMed Research International·Roger Maldonado-RuizAlberto Camacho
Mar 9, 2021·Frontiers in Nutrition·Alistaire D RuggieroKylie Kavanagh
Nov 5, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Ivan LiakhAdriana Mika

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Clinical Nutrition and Metabolic Care
Chaonan FanKemin Qi
The Proceedings of the Nutrition Society
María J Moreno-AliagaJ Alfredo Martínez
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
M A Lazar
© 2021 Meta ULC. All rights reserved