PMID: 12540389Jan 24, 2003Paper

n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study

The American Journal of Clinical Nutrition
Rozenn N LemaitreDavid S Siscovick


Little is known about the relation of the dietary intake of n-3 polyunsaturated fatty acids, ie, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from fatty fish and alpha-linolenic acid from vegetable oils, with ischemic heart disease among older adults. We investigated the associations of plasma phospholipid concentrations of DHA, EPA, and alpha-linolenic acid as biomarkers of intake with the risk of incident fatal ischemic heart disease and incident nonfatal myocardial infarction in older adults. We conducted a case-control study nested in the Cardiovascular Health Study, a cohort study of adults aged > or = 65 y. Cases experienced incident fatal myocardial infarction and other ischemic heart disease death (n = 54) and incident nonfatal myocardial infarction (n = 125). Matched controls were randomly selected (n = 179). We measured plasma phospholipid concentrations of n-3 polyunsaturated fatty acids in blood samples drawn approximately 2 y before the event. A higher concentration of combined DHA and EPA was associated with a lower risk of fatal ischemic heart disease, and a higher concentration of alpha-linolenic acid with a tendency to lower risk, after adjustment for risk factors [odds ratio: 0.32 (95% CI: 0.13, ...Continue Reading


Jun 1, 1992·American Heart Journal·P L McLennanJ S Charnock
Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
May 9, 1985·The New England Journal of Medicine·D KromhoutC de Lezenne Coulander
Nov 1, 1995·JAMA : the Journal of the American Medical Association·D S SiscovickL H Kushi
Apr 1, 1995·International Journal of Epidemiology·D KromhoutC H Bowles
Sep 1, 1995·American Journal of Epidemiology·J A SimonS B Hulley
Apr 13, 1995·The New England Journal of Medicine·A AscherioW C Willett
Jul 13, 1996·BMJ : British Medical Journal·A AscherioW C Willett
Apr 10, 1997·The New England Journal of Medicine·M L DaviglusR B Shekelle
Apr 1, 1997·The American Journal of Clinical Nutrition·S K KumanyikaV M Chinchilli
Nov 20, 1997·The New England Journal of Medicine·F B HuW C Willett
Jan 10, 1998·JAMA : the Journal of the American Medical Association·C M AlbertJ E Manson
Mar 3, 1998·European Journal of Clinical Nutrition·A ChisholmS Tiszavari
May 8, 1999·The American Journal of Clinical Nutrition·F B HuW C Willett
Jun 9, 1999·International Journal of Cancer. Journal International Du Cancer·J A SatiaM A Rossing
Nov 7, 1999·The Journal of Membrane Biology·A LeafR A Voskuyl
Jan 5, 2000·The American Journal of Clinical Nutrition·D S SiscovickR H Knopp
Apr 10, 2002·JAMA : the Journal of the American Medical Association·Frank B HuJoAnn E Manson
Apr 12, 2002·The New England Journal of Medicine·Christine M AlbertJing Ma

❮ Previous
Next ❯


May 9, 2003·The New England Journal of Medicine·Suliman A AhmedColm McGurk
Jun 11, 2004·Annual Review of Nutrition·Vasuki Wijendran, K C Hayes
May 11, 2004·The American Journal of Geriatric Cardiology·Dariush MozaffarianDavid S Siscovick
Jul 16, 2005·Journal of Microencapsulation·L H TanP W S Heng
Sep 12, 2006·Upsala Journal of Medical Sciences·Rowa Jabbar, Tom Saldeen
Aug 7, 2007·The British Journal of Nutrition·Francesca L CroweAndrew R Gray
Aug 12, 2008·Journal of the American College of Nutrition·J Alejandro AustriaGrant N Pierce
Dec 10, 2008·The American Journal of Clinical Nutrition·Jyrki K VirtanenEric B Rimm
Dec 25, 2008·The British Journal of Nutrition·Robert ClarkeWilliam Harris
May 27, 2010·Nutrition Reviews·Rebecca WallCatherine Stanton
Mar 12, 2010·The American Journal of Clinical Nutrition·Renate C Heine-BröringJohanna M Geleijnse
Oct 15, 2010·The American Journal of Clinical Nutrition·Dariush MozaffarianGökhan S Hotamisligil
May 20, 2011·The American Journal of Clinical Nutrition·Luc DjousséDariush Mozaffarian
Jun 24, 2011·The American Journal of Clinical Nutrition·Jason H Y WuDariush Mozaffarian
Dec 12, 2012·The American Journal of Clinical Nutrition·Leah G GillinghamPeter J H Jones
Oct 3, 2012·International Journal of Nephrology·Hiroyuki ImamuraReika Oshikata
Dec 18, 2013·European Journal of Preventive Cardiology·Angela S KohWoon-Puay Koh
Nov 14, 2013·Pediatric Gastroenterology, Hepatology & Nutrition·Ji-Hyuk Lee
Dec 20, 2013·Journal of the American Heart Association·Marcia C de Oliveira OttoDariush Mozaffarian
Aug 28, 2014·The British Journal of Nutrition·Amanda M FrettsRozenn N Lemaitre
Jun 28, 2014·Journal of the American Heart Association·Amanda M FrettsRozenn N Lemaitre
Dec 8, 2014·BMC Complementary and Alternative Medicine·Miriam Adoyo Muga, Jane C-J Chao
Jan 14, 2016·European Journal of Clinical Nutrition·E M González-GilL A Moreno
Dec 29, 2018·Nutrients·Maria Alessandra GammoneNicolantonio D'Orazio
Mar 11, 2020·Open Heart·James J DiNicolantonio, James OKeefe
Oct 16, 2004·Fundamental & Clinical Pharmacology·Delphine Yzebe, Michel Lievre
Aug 30, 2003·European Journal of Clinical Nutrition·P Mata López, R M Ortega

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.