n-3 PUFA status affects expression of genes involved in neuroenergetics differently in the fronto-parietal cortex compared to the CA1 area of the hippocampus: effect of rest and neuronal activation in the rat

Prostaglandins, Leukotrienes, and Essential Fatty Acids
Emilie HarbebyPhilippe Guesnet

Abstract

n-3 Polyunsaturated fatty acids (PUFA) support whole brain energy metabolism but their impact on neuroenergetics in specific brain areas and during neuronal activation is still poorly understood. We tested the effect of feeding rats as control, n-3 PUFA-deficient diet, or docosahexaenoic acid (DHA)-supplemented diet on the expression of key genes in fronto-parietal cortex and hippocampal neuroenergetics before and after neuronal stimulation (activated) by an enriched environment. Compared to control rats, n-3 deficiency specifically repressed GLUT1 gene expression in the fronto-parietal cortex in basal state and also during neuronal activation which specifically stimulated GLUT1. In contrast, in the CA1 area, n-3 deficiency improved the glutamatergic synapse function in both neuronal states (glutamate transporters, Na(+)/K(+) ATPase). DHA supplementation induced overexpression of genes encoding enzymes of the oxidative phosphorylation system and the F1F0 ATP synthase in the CA1 area. We conclude that n-3 deficiency repressed GLUT1 gene expression in the cerebral cortex, while DHA supplementation improved the mitochondrial ATP generation in the CA1 area of the hippocampus.

References

Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Pellerin, P J Magistretti
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J VissingN H Diemer
Mar 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaTibor Farkas
Jun 18, 2002·Journal of Neurochemistry·Adriana Ximenes da SilvaMonique Lavialle
Jun 5, 2003·Biochimica Et Biophysica Acta·Gwendolyn Barceló-CoblijnTibor Farkas
Oct 8, 2003·Pflügers Archiv : European journal of physiology·Yoshikatsu Kanai, Matthias A Hediger
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Klára KitajkaLászló G Puskás
Nov 16, 2004·Trends in Neurosciences·Leif Hertz, H Ronald Zielke
Dec 14, 2004·Neuroscience·C ChoeiriC Messier
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Luc Leybaert
Mar 15, 2005·Reproduction, Nutrition, Development·Jean-Marc AlessandriMonique Lavialle
Sep 12, 2006·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sylvie Chalon
Dec 22, 2006·Nutrition and Health·Laszlo G Puskas, Klara Kitajka
Jul 31, 2007·Glia·Luc PellerinPierre J Magistretti
Nov 29, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F PifferiP Guesnet
Feb 14, 2008·Nature Reviews. Neuroscience·Nelson Spruston
Sep 16, 2008·Brain Research·Sheila M Innis
Jan 9, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Elizabeth SubletteJ John Mann
Jan 23, 2009·The Journal of Nutritional Biochemistry·Audrey ExtierJean-Marc Alessandri
Apr 14, 2009·Progress in Lipid Research·S C CunnaneP Barberger-Gateau
Aug 18, 2009·Journal of Neurochemistry·Dehua CaoHee-Yong Kim
Oct 7, 2009·Prostaglandins & Other Lipid Mediators·Tiffany D Niemoller, Nicolas G Bazan
Feb 16, 2010·Neurochemistry International·Fabien PifferiPhilippe Guesnet
Dec 25, 2010·Neuropsychologia·Akiko Ikkai, Clayton E Curtis

❮ Previous
Next ❯

Citations

Jun 4, 2015·Developmental Neurobiology·Elise MaximinChristine Heberden
Jun 26, 2013·Maternal & Child Nutrition·William Day Lassek, Steven J C Gaulin
Nov 26, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Francis E LotrichRobert K McNamara
Nov 5, 2013·Journal of Psychosomatic Research·Francis E LotrichRobert K McNamara
Jun 29, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sarah AfshordelGunter P Eckert
Jan 24, 2015·Psychoneuroendocrinology·Amandine L LépinayMuriel Darnaudéry
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Navneet AgnihotriArchana Bhatnagar
Jul 13, 2019·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Bao-Qiang GuoHong-Bin Li
Apr 28, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peiyan Ni, Sangmi Chung
May 27, 2021·The Journal of Nutritional Biochemistry·Alinny Rosendo IsaacRicardo Augusto de Melo Reis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.