May 1, 1977

N-(4-Acetamidophenyl)-anti-tricyclo [4.2.2.025-] deca-3, 9-diene-7, 8-endodicarboximide (1)--a chemically novel anticonvulsant

Archives Internationales De Pharmacodynamie Et De Thérapie
V J Lotti

Abstract

The present report describes the activity of a dicarboximide in various test procedures in mice believed to define the therapeutic efficacy to compounds as antiepileptic agents. Comparative studies with diphenylhydantoin, phenobarbital and trimethadione have shown the profile of activity, potency and duration of action of the dicarboximide to closely resemble diphenylhydantoin. This dicarboximide is chemically novel in relation to presently employed therapeutic agents and could offer promise as a new class of agents with potential value in the treatment of convulsive disorders.

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Mentioned in this Paper

Deca
Anticonvulsants
Motor Skills
Imides
Phenobarbital
Therapeutic Agent
Antiepileptic Agents
Trimethadione
Non-epileptic Convulsion
Chemicals

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