PMID: 3756133Jul 29, 1986Paper

N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C

Biochemistry
M ItoH Hidaka

Abstract

Naphthalenesulfonamide derivatives were used to study the mechanism of regulation of Ca2+-dependent smooth muscle myosin light chain phosphorylation catalyzed by Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C) and myosin light chain kinase. Derivatives such as N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide (SC-9), with a hydrophobic residue at the end of a hydrocarbon chain, stimulated Ca2+-activated, phospholipid-dependent myosin light chain phosphorylation in a Ca2+-dependent fashion. There was no significant effect of these compounds on Ca2+-calmodulin (CaM) dependent myosin light chain phosphorylation. On the other hand, derivatives with the guanidino or amino residue at the same position had an inhibitory effect on both Ca2+-phospholipid- and Ca2+-CaM-dependent myosin light chain phosphorylation. These observations suggest that activation of Ca2+-activated, phospholipid-dependent myosin light chain phosphorylation by naphthalenesulfonamide derivatives depends on the chemical structure at the end of hydrocarbon chain of each compound. SC-9 was similar to phosphatidylserine with regard to activation, and the apparent Km values for Ca2+ of the enzyme with this compound and phosphatidylserine were...Continue Reading

References

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Citations

Jan 1, 1993·Medicinal Research Reviews·Y NomuraY Tokumitsu
Dec 17, 1993·Pharmacy World & Science : PWS·R K Sweeb, J H Beijnen
Jan 1, 1989·Life Sciences·M PicqH Pacheco
Apr 15, 1994·European Journal of Pharmacology·D M Helmeste, S W Tang
Mar 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·M YonemaruK Toyama
Jun 1, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·K AshizawaY Tsuzuki
Feb 24, 2009·Trends in Biochemical Sciences·T J Nelson, D L Alkon
Jan 1, 2009·Molecular Reproduction and Development·Stephen A Stricker
Feb 14, 1990·Biochemical and Biophysical Research Communications·E BignonY Nishizuka
Jan 26, 1987·FEBS Letters·F HuchoU Oberdieck

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